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Vaccination against the helminth nematode <jats:italic>Trichinella<\/jats:italic> could be a good strategy to reduce the risk of human and animal infection. It was our aim to evaluate three adjuvants, which could be used as an efficient vaccine for animals in combination with <jats:styled-content style=\"fixed-case\">rT<\/jats:styled-content>s\u2010Serpin antigen. In this study, <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice were vaccinated by an intramuscular route with <jats:styled-content style=\"fixed-case\">rT<\/jats:styled-content>s\u2010Serpin antigen from the parasite <jats:italic>Trichinella spiralis<\/jats:italic> in combination with three different adjuvant formulations: Montanide <jats:styled-content style=\"fixed-case\">ISA<\/jats:styled-content>201, Montanide <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> 1313 N <jats:styled-content style=\"fixed-case\">PR VG<\/jats:styled-content> and Freund's complete adjuvant\/Freund's incomplete adjuvant (<jats:styled-content style=\"fixed-case\">FCA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FIA<\/jats:styled-content>). The dynamics of IgG, IgM, IgE and cytokine production from spleen cells and worm reduction rate of the vaccinated mice were analysed. The results showed that <jats:styled-content style=\"fixed-case\">rT<\/jats:styled-content>s\u2010serpin can induce partial protection against <jats:italic>Trichinella<\/jats:italic> larvae challenge in mice, when compared to the <jats:styled-content style=\"fixed-case\">FCA<\/jats:styled-content>\u2010\/<jats:styled-content style=\"fixed-case\">FIA<\/jats:styled-content>\u2010formulated vaccination, the <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content>1313 plus <jats:styled-content style=\"fixed-case\">rT<\/jats:styled-content>s\u2010serpin mixture showed higher humoral immunity and similar levels of cellular immunity and worm reduction rate. The study suggested that Montanide <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> nanoparticles 1313 are as effective as <jats:styled-content style=\"fixed-case\">FCA<\/jats:styled-content> but less toxic; thus, Montanide <jats:styled-content style=\"fixed-case\">IMS<\/jats:styled-content> nanoparticles 1313 can be used as a good candidate of adjuvant for developing vaccine against <jats:italic>Trichinella spiralis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pim.12437","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T16:23:08Z","timestamp":1493223788000},"source":"Crossref","is-referenced-by-count":19,"title":["Influence of adjuvant formulation on inducing immune response in mice immunized with a recombinant serpin from <i>Trichinella spiralis<\/i>"],"prefix":"10.1111","volume":"39","author":[{"given":"J.","family":"Xu","sequence":"first","affiliation":[{"name":"Key Lab for Zoonoses Research Ministry of Education Institute of Zoonoses Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Lab for Zoonoses Research Ministry of Education Institute of Zoonoses Jilin University  Changchun PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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