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Filarial parasites traverse or establish niches in the skin (migrating infective larvae), in nonmucosal tissues (adult parasite niche) and in the blood or skin (circulating microfilariae) where they intersect with the host immune response. While several studies have demonstrated that filarial parasites and their antigens can modulate myeloid cells (monocyte, macrophage and dendritic cell subsets), T\u2010 and B\u2010lymphocytes and skin resident cell populations, the role of innate lymphoid cells during filarial infections has only recently emerged. Despite the identification and characterization of innate lymphoid cells (<jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>s) in murine helminth infections, little is actually known about the role of human <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>s during parasitic infections. 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