{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:43:04Z","timestamp":1790775784981,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010179","name":"University of Northern Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI076233"],"award-info":[{"award-number":["AI076233"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI045540"],"award-info":[{"award-number":["AI045540"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01BX001983"],"award-info":[{"award-number":["5I01BX001983"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["2I01BX000536"],"award-info":[{"award-number":["2I01BX000536"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Lipid bodies (<jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s) are intracellular accumulations of neutral lipids surrounded by a single membrane. These organelles are involved in the production of eicosanoids, which modulate immunity by either promoting or dampening inflammatory responses. <jats:italic>Leishmania infantum<\/jats:italic>, the etiological agent of visceral leishmaniasis in Brazil, is an intracellular parasite that causes disease by suppressing macrophage microbicidal responses. C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mouse bone marrow\u2010derived macrophages infected with <jats:italic>L. infantum<\/jats:italic> strain LcJ had higher numbers of <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>+ cells (<jats:italic>P<\/jats:italic>&lt;.0001) and total <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s than noninfected cultures. Large (&gt;3\u00a0\u03bcm) <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s were present inside parasitophorous vacuoles (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>s). These results contrast with those of <jats:italic>L. infantum<\/jats:italic>\u2010infected <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c macrophages, in which the only <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s are derived from parasite, not macrophage origin. Increased <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s in C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 macrophages in close association with parasites would position host <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s where they could modulate <jats:italic>L. infantum<\/jats:italic> infection. These results imply a potential influence of the host genetics on the role of <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s in host\u2010pathogen interactions. Overall, our data support a model in which the expression, and the role of <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s upon infection, ultimately depends on the specific combination of host\u2010pathogen interactions.<\/jats:p>","DOI":"10.1111\/pim.12443","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T16:11:03Z","timestamp":1495123863000},"source":"Crossref","is-referenced-by-count":29,"title":["Lipid bodies accumulation in <i>Leishmania infantum<\/i>\u2010infected C57<scp>BL<\/scp>\/6 macrophages"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-3680","authenticated-orcid":false,"given":"N. E.","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Biology University of Northern Iowa  Cedar Falls IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Lockard","sequence":"additional","affiliation":[{"name":"Department of Biology University of Northern Iowa  Cedar Falls IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Turcotte","sequence":"additional","affiliation":[{"name":"Department of Biology University of Northern Iowa  Cedar Falls IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ara\u00fajo\u2010Santos","sequence":"additional","affiliation":[{"name":"Center of Biological Sciences and Health Federal University of Western Bahia (UFOB)  Barreiras BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. T.","family":"Bozza","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology Oswaldo Cruz Institut Oswaldo Cruz Foundation (FIOCRUZ)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. M.","family":"Borges","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institut Oswaldo Cruz Foundation (FIOCRUZ)  Salvador BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa  Iowa City IA USA"},{"name":"Department of Microbiology University of Iowa  Iowa City IA USA"},{"name":"Veterans\u2019 Affairs Medical Center  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fimmu.2016.00153","article-title":"The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis","volume":"7","author":"de Freitas EO","year":"2016","journal-title":"Front Immunol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002729"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.10.028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-153958"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00174"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.06.060"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2010.01533.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12279"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu299"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148640"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712241105"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-014-0601-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.1.1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001763"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000873"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004866"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.11.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002276"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160433"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:26:37Z","timestamp":1696188397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,16]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/pim.12443"],"URL":"https:\/\/doi.org\/10.1111\/pim.12443","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,16]]},"article-number":"e12443"}}