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The extracellular matrix degradation during cardiac remodeling in <jats:italic>Trypanosoma cruzi<\/jats:italic> infection is driven by matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s), primarily the <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 gelatinases. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s also regulate some molecules related to inflammation, such as growth factors, cytokines and chemokines. The involvement of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 is not yet fully understood in Chagas' disease. It has been proposed that the gelatinases may have opposite effect on inflammation\/regulation and cardiac remodeling. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 would participate in regulation, offering a protective role for cardiac damage in asymptomatic patients and would be a good marker for the initiation of changes in the heart. On the other hand, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 can be used as a marker for serious changes on the heart and would be associated with inflammation and fibrosis. Here, we consolidate all characteristics involving <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 in Chagas' disease based on current studies to clarify their participation on the inflammation\/regulation and fibrosis, and the synergistic or antagonistic role between them.<\/jats:p>","DOI":"10.1111\/pim.12446","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:49:35Z","timestamp":1495730975000},"source":"Crossref","is-referenced-by-count":36,"title":["Synergic and antagonistic relationship between <scp>MMP<\/scp>\u20102 and <scp>MMP<\/scp>\u20109 with fibrosis and inflammation in Chagas' cardiomyopathy"],"prefix":"10.1111","volume":"39","author":[{"given":"N. 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