{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:42Z","timestamp":1791398322239,"version":"4.3.3"},"reference-count":156,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["JA 1479\/5\u20101"],"award-info":[{"award-number":["JA 1479\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001275","name":"Oak Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Group 2 innate lymphoid cells (<jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s) play crucial roles in type 2 immune responses associated with allergic and autoimmune diseases, viral and helminth infections and tissue homoeostasis. Experimental models show that in helminth infections <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s provide an early source of type 2 cytokines and therefore are essential for the induction of potentially protective type 2 responses. Much of our knowledge of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s in helminth infections has come from experimental mouse models with very few studies analysing <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s in natural human infections. In attempts to harness knowledge from paradigms of the development of protective immunity in human helminth infections for vaccine development, the role of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 cells could be pivotal. So far, potential vaccines against human helminth infections have failed to provide effective protection when evaluated in human studies. In addition to appropriate antigen selection, it is apparent that more detailed knowledge on mechanisms of induction and maintenance of protective immune responses is required. Therefore, there is need to understand how <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 cells induce type 2 responses and subsequently support the development of a protective immune response in the context of immunizations. Within this review, we summarize the current knowledge of the biology of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s, discuss the importance of <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2s in human helminth infections and explore how <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>2 responses could be boosted to efficiently induce protective immunity.<\/jats:p>","DOI":"10.1111\/pim.12450","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T06:06:36Z","timestamp":1497852396000},"source":"Crossref","is-referenced-by-count":21,"title":["Group 2 <scp>ILC<\/scp>s: A way of enhancing immune protection against human helminths?"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-2148","authenticated-orcid":false,"given":"N.","family":"Nausch","sequence":"first","affiliation":[{"name":"Pediatric Pneumology and Infectious Diseases Group, Department of General Pediatrics, Neonatology and Pediatric Cardiology University Children's Hospital, Heinrich\u2010Heine\u2010University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mutapi","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution School of Biological Sciences, University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08900"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003988107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3365"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3BT0814-383R"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5BT0814-374R"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2617"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/intimm\/dxv050","article-title":"Group 2 innate lymphoid cells in disease","volume":"28","author":"Halim TY","year":"2016","journal-title":"Int Immunol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3059"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2131"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3489"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003627"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051615"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08636"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3892"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075053"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2208"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200010)30:10<2972::AID-IMMU2972>3.0.CO;2-#"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14115"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2551"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3444"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004812"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3308"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.020"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.015"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05128.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63631-0"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606854104"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003331"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-11-52"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2011.07.005"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16527"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1648"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16161"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.04.013"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130071"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2133"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.59"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.3.1278"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.2013"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.2.255"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.21"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.016"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.05.019"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3309"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130351"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.012"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301228"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2743"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1226"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141718"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.091003.090312"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2633"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-392738"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.09.009"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.02.006"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5122"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-232330"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5788"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636401"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00506.x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2584"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.056"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.146"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182010001216"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2014.11.002"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2310047"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.406"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12102"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2628"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.001"},{"key":"e_1_2_10_73_1","first-page":"e12429","article-title":"The role of ILC2 in hookworm infection","volume":"00","author":"Filbey K","year":"2017","journal-title":"Parasite Immunol"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/b101298"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102039"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.007"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.04.007"},{"key":"e_1_2_10_78_1","first-page":"379","volume-title":"The Biology of Schistosomes: From Genes to Latrines","author":"Wilkins HA","year":"1987"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005374"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.037"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.038"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108649"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005156"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2010.01235.x"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00472"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332949"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02095-X"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091509"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900863"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-007-0062-1"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66591-9"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000191919.24185.46"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535111"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.02.014"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903758"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222303110"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006425"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03326.x"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247606"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151448"},{"key":"e_1_2_10_101_1","unstructured":"FAO IFAD WFP.The State of Food Insecurity in the World 2015: Meeting the 2015 international hunger targets: taking stock of uneven progress.Rome:FAO;2015."},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125945"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003861"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18847"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0341-9"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1412"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2585"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.018"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600418"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01551-0"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0629"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.11.034"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05040-11"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2992"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091903"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1183"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001655"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904067"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016860"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.676"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101074"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2008.01043.x"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002237"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.123"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/351757a0"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1086\/432553"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.01.003"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21060"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-11-56"},{"key":"e_1_2_10_130_1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1086\/649841","article-title":"Induction of type 2 responses by schistosome worms during prepatent infection","volume":"201","author":"Oliveira Fraga LA","year":"2010","journal-title":"J Infect Dis"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805832"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60360-7"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2007.03.009"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1490019"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105143"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.01.001"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0049"},{"key":"e_1_2_10_138_1","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1182\/blood.V78.6.1538.1538","article-title":"Administration of interleukin\u20102 (IL\u20102) results in increased plasma concentrations of IL\u20105 and eosinophilia in patients with cancer","volume":"78","author":"Haelst PisaniC","year":"1991","journal-title":"Blood"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-005-0701-6"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-587493"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3823"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1953"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160510267"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.3109\/15476910903453296"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.01.011"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.008"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.11.005"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133774"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.15.36"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.14"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402895"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201042109"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00056-X"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.011"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121964"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300974"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3294"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:30:15Z","timestamp":1694626215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,12]]},"references-count":156,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/pim.12450"],"URL":"https:\/\/doi.org\/10.1111\/pim.12450","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,12]]},"article-number":"e12450"}}