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Here, we investigated the mechanisms involved on the suppressive effect of <jats:italic>Ascaris suum<\/jats:italic> infection using a murine experimental model of LPS\u2010induced inflammation. We found that infection with <jats:italic>A.\u00a0suum<\/jats:italic> markedly inhibited leucocyte influx induced by LPS into air pouches, suppressed secretion of pro\u2010inflammatory cytokines (IL\u20101\u03b2, TNF\u2010\u03b1 and IL\u20106) and induced high levels of IL\u201010 and TGF\u2010\u03b2. Augmented frequency of CD4<jats:sup>+<\/jats:sup> CD25<jats:sup>high<\/jats:sup> Foxp3<jats:sup>+<\/jats:sup> T cells was observed in the mesenteric lymph nodes of infected mice. Adoptive transfer of purified CD4<jats:sup>+<\/jats:sup> CD25<jats:sup>+<\/jats:sup> T cells to recipient uninfected mice demonstrated that these cells were able to induce a suppressive effect in the LPS\u2010induced inflammation in air pouch model. In addition, adoptive transfer of CD4<jats:sup>+<\/jats:sup> CD25<jats:sup>+<\/jats:sup> T cells derived from IL\u201010 knockout mice suggests that this suppressive effect of <jats:italic>A.\u00a0suum<\/jats:italic> infection involves IL\u201010 cytokine. In conclusion, our results demonstrated that <jats:italic>A.\u00a0suum<\/jats:italic> experimental infection was capable of suppressing LPS\u2010induced inflammation by mechanisms, which seem to be dependent on responses of CD4<jats:sup>+<\/jats:sup> CD25<jats:sup>+<\/jats:sup> T cells and secretion of IL\u201010 cytokine.<\/jats:p>","DOI":"10.1111\/pim.12453","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T14:02:15Z","timestamp":1499954535000},"source":"Crossref","is-referenced-by-count":9,"title":["<i>Ascaris suum<\/i> infection modulates inflammation: Implication of CD4<sup>+<\/sup> CD25<sup>high<\/sup> Foxp3<sup>+<\/sup> T cells and IL\u201010"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-8143","authenticated-orcid":false,"given":"T. de O.","family":"Titz","sequence":"first","affiliation":[{"name":"Laboratory of Immunopathology Butantan Institute  S\u00e3o Paulo Brazil"},{"name":"Laboratorio de Investigacao em Dermatologia e Imunodeficiencias LIM56 Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de S\u00e3o Paulo  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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