{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:22:47Z","timestamp":1778703767075,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002805","name":"Carl Tryggers Stiftelse f\u00f6r Vetenskaplig Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007508","name":"Stiftelsen Sigurd and Elsa Goljes Minne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007508","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Low\u2010 and high\u2010dose infections with the murine large intestinal nematode <jats:italic>Trichuris muris<\/jats:italic> are associated with induction of adaptive Th1 and Th2 responses, respectively, in mesenteric lymph nodes (<jats:styled-content style=\"fixed-case\">MLN<\/jats:styled-content>). Classical dendritic cells (<jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content>) accumulate in the large intestinal mucosa and <jats:styled-content style=\"fixed-case\">MLN<\/jats:styled-content> upon <jats:italic>T. muris<\/jats:italic> infection, yet their role in driving adaptive responses to infection remains largely unknown. We performed low\u2010 and high\u2010dose <jats:italic>T. muris<\/jats:italic> infections of mice deficient in defined <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content> subsets to investigate their role in induction of adaptive immune responses. Mice lacking <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>4\u2010dependent <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content> failed to clear a high\u2010dose infection and displayed impaired Th2 responses. Conversely, mice lacking <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>8\u2010dependent <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content> cleared a low\u2010dose infection and displayed an impaired Th1 response while increased production of Th2 cytokines. Finally, mice lacking both <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>4\u2010 and <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>8\u2010dependent <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content> were able to generate a Th2 response and clear a low\u2010dose infection. Collectively, these results suggest that <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>4\u2010 and <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>8\u2010dependent <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content> act antagonistically during <jats:italic>T. muris<\/jats:italic> infection, and demonstrate that intestinal Th2 responses can be generated towards <jats:italic>T. muris<\/jats:italic> in the absence of <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>4\u2010dependent <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pim.12458","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T14:26:35Z","timestamp":1502547995000},"source":"Crossref","is-referenced-by-count":17,"title":["Distinct <scp>DC<\/scp> subsets regulate adaptive Th1 and 2 responses during <i>Trichuris muris<\/i> infection"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-1010","authenticated-orcid":false,"given":"M.","family":"Demiri","sequence":"first","affiliation":[{"name":"Immunology Section Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"M\u00fcller\u2010Luda","sequence":"additional","affiliation":[{"name":"Immunology Section Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. W.","family":"Agace","sequence":"additional","affiliation":[{"name":"Immunology Section Lund University  Lund Sweden"},{"name":"Section of Immunology and Vaccinology National Veterinary Institute Technical University of Denmark  Lyngby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Svensson\u2010Frej","sequence":"additional","affiliation":[{"name":"Immunology Section Lund University  Lund Sweden"},{"name":"Section of Immunology and Vaccinology National Veterinary Institute Technical University of Denmark  Lyngby 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