{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:54:31Z","timestamp":1789818871364,"version":"4.0.1"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010679","name":"Pasteur Institute of Iran","doi-asserted-by":"crossref","award":["IPI 705"],"award-info":[{"award-number":["IPI 705"]}],"id":[{"id":"10.13039\/501100010679","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recent findings have demonstrated the suitability of interferon\u2010gamma\u2010induced protein 10 (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010) or <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 as an immunotherapy tool in treatment of leishmaniasis. This chemokine can overcome <jats:italic>Leishmania<\/jats:italic> (<jats:italic>L<\/jats:italic>.) infection through inducing nitric oxide (NO) production for parasite elimination. This study was undertaken to investigate the therapeutic effects of recombinant <jats:italic>Leishmania tarentolae<\/jats:italic> expressing <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 and an expression vector encoding <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 (pc<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010\u2010<jats:styled-content style=\"fixed-case\">EGFP<\/jats:styled-content>) in a model of <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice susceptible to infection by <jats:italic>Leishmania major<\/jats:italic>. The outcome of intervention was examined at 3\u00a0weeks post\u2010treatment by evaluating the parameters of parasite burden (PB), arginase activity, NO and various cytokines such as <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010. The results have shown that despite the efficacy of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 expression vector as gene therapy, the live therapy strategy using <jats:italic>L<\/jats:italic>.\u00a0<jats:italic>tarentolae<\/jats:italic> expressing <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 was more effective in terms of decreasing PB. Nitric oxide production increased, especially in the live therapy approaches. Arginase activity also decreased in all regimens, which demonstrates the potency of the treatment. The overall cytokine production shifted in favour of Th1 responses in the treated mice. Altogether, recombinant <jats:italic>L.\u00a0tarentolae<\/jats:italic> expressing <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 represents a promising therapeutic strategy to improve treatment of cutaneous leishmaniasis.<\/jats:p>","DOI":"10.1111\/pim.12461","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T14:52:38Z","timestamp":1503067958000},"source":"Crossref","is-referenced-by-count":20,"title":["<i>Leishmania tarentolae<\/i> expressing <scp>CXCL<\/scp>\u201010 as an efficient immunotherapy approach against <i>Leishmania major<\/i>\u2010infected <scp>BALB<\/scp>\/c mice"],"prefix":"10.1111","volume":"39","author":[{"given":"H.","family":"Montakhab\u2010Yeganeh","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Faculty of Medical Sciences Tarbiat Modares University  Tehran 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