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In addition to neuronal and ocular pathologies, this pathogen also causes gut inflammation in a number of animals. This infection\u2010triggered inflammation has been extensively studied in the C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice, highlighting the importance of the immune cells and their mediators in the development of gut pathology. However, despite their importance in inflammation, the role of protease\u2010activated receptors (<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>) was never reported in the context of <jats:italic>T.gondii<\/jats:italic>\u2010mediated small intestine inflammation. Using genetically modified mice, we show that <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content><jats:sub>2<\/jats:sub> plays a pathogenic role in the development of gut inflammatory lesions. We find that <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content><jats:sub>2<\/jats:sub> controls the innate inflammatory mediators <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content><jats:sub>2<\/jats:sub> as well as neutrophil infiltration in <jats:italic>T. gondii\u2010<\/jats:italic>triggered gut damage. These results bring new knowledge on the mechanisms operating in the gut in response to <jats:italic>T. gondii<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/pim.12489","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T14:01:50Z","timestamp":1504792910000},"source":"Crossref","is-referenced-by-count":17,"title":["Protease\u2010activated receptor 2 contributes to <i>Toxoplasma gondii<\/i>\u2010mediated gut inflammation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-492X","authenticated-orcid":false,"given":"C.","family":"Bonnart","sequence":"first","affiliation":[{"name":"Institut de Recherche en Sant\u00e9 Digestive (IRSD) Universit\u00e9 de Toulouse INSERM, INRA, ENVT, UPS  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Feuillet","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sant\u00e9 Digestive (IRSD) Universit\u00e9 de 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