{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:49:22Z","timestamp":1772268562055,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["1265790"],"award-info":[{"award-number":["1265790"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000145","name":"Alberta Innovates - Health Solutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Infection with parasitic helminths can ameliorate the severity of concomitant inflammatory disease. To use the tapeworm, <jats:italic>Hymenolepis diminuta<\/jats:italic>, and to extend this concept by assessing whether triggering a memory response against the worm inhibits dinitrobenzene sulphonic acid (<jats:styled-content style=\"fixed-case\">DNBS<\/jats:styled-content>)\u2010induced colitis in Balb\/c mice. Initial studies revealed that oral infection with 1, 3 or 5 <jats:italic>H.\u00a0diminuta<\/jats:italic> cysticercoids 8\u00a0days before intrarectal administration of <jats:styled-content style=\"fixed-case\">DNBS<\/jats:styled-content> (3\u00a0mg) resulted in less severe inflammation and that infected mice displayed an increased propensity for T helper\u20102 immunity. A 1\u00a0mg dose of a <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>\u2010soluble extract of the worm (<jats:italic>Hd<\/jats:italic>Ag) delivered intraperitoneally concomitant with <jats:styled-content style=\"fixed-case\">DNBS<\/jats:styled-content> was anticolitic as determined by macroscopic and histological disease scores 72\u00a0hour post\u2010<jats:styled-content style=\"fixed-case\">DNBS<\/jats:styled-content>. Mice infected 28\u00a0days previously had a memory response as determined by <jats:italic>Hd<\/jats:italic>Ag\u2010evoked increases in interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 from in vitro stimulated splenocytes and serum anti\u2010<jats:italic>H.\u00a0diminuta<\/jats:italic> IgG. Moreover, mice infected with 5 <jats:italic>H.\u00a0diminuta<\/jats:italic> 28\u00a0days previously were protected from <jats:styled-content style=\"fixed-case\">DNBS<\/jats:styled-content>\u2010induced colitis by secondary infection or 100\u00a0\u03bcg <jats:italic>Hd<\/jats:italic>Ag (ip.) at the time of <jats:styled-content style=\"fixed-case\">DNBS<\/jats:styled-content> treatment. An additional approach to managing inflammatory disease could be infection with <jats:italic>H.\u00a0diminuta<\/jats:italic> followed by eliciting antiworm recall responses.<\/jats:p>","DOI":"10.1111\/pim.12490","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T16:12:51Z","timestamp":1505146371000},"source":"Crossref","is-referenced-by-count":8,"title":["Triggering immunological memory against the tapeworm <i>Hymenolepis diminuta<\/i> to protect against colitis"],"prefix":"10.1111","volume":"39","author":[{"given":"A.","family":"Wang","sequence":"first","affiliation":[{"name":"Gastrointestinal Research Group and Inflammation Research Network Department of Physiology and Pharmacology Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases Cumming School of Medicine University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Arai","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Group and Inflammation Research Network Department of Physiology and Pharmacology Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases Cumming School of Medicine University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Group and Inflammation Research Network Department of Physiology and Pharmacology Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases Cumming School of Medicine University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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