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Macrophages obtained from 15 healthy dogs were cultured alone or infected with <jats:italic>L. infantum<\/jats:italic>, with or without association of <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\u20101 inducer and inhibitor. The infection rate and the parasite load were determined by the number of infected macrophages and number of promastigotes per macrophage, respectively. <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\u20101 levels and gene expression, as well as <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha levels were also measured in these cultures. Superoxide, <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> levels in macrophages were measured through flow cytometry. Induction of <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\u20101 increased the infection rate and parasite load, while its inhibition decreased the infection rate and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 production. There was a positive correlation between <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\u20101 and infection rate or parasite load. Increased infection rate was associated with decreased superoxide, <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> levels. Induction of <jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\u20101 metabolism in dogs infected by <jats:italic>L. infantum<\/jats:italic> is possibly one of the mechanisms responsible for increasing the infection of macrophages, mainly through reduction in the oxidative and nitrosative metabolisms of these cells.<\/jats:p>","DOI":"10.1111\/pim.12494","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T08:46:35Z","timestamp":1505897195000},"source":"Crossref","is-referenced-by-count":6,"title":["Induction of haem oxygenase\u20101 increases infection of dog macrophages by <i>L. infantum<\/i>"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-6734","authenticated-orcid":false,"given":"B. F. 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