{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:15:39Z","timestamp":1767212139073,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["Fondo Sectorial de Salud 140091"],"award-info":[{"award-number":["Fondo Sectorial de Salud 140091"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Pentalinon andrieuxii<\/jats:italic>Muell Arg is a Mexican\u2010Central American plant anciently used by local people to treat cutaneous leishmaniasis. We evaluated a hexane extract of the root we called<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>for its chemical content and for its immunochemical and in vitro activity against<jats:italic>Leishmania donovani<\/jats:italic>and healing of experimental Kala\u2010azar. Chemical analysis using gas chromatography coupled to mass spectrometry (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) identified hexadecanoic acid, hexadecanoic acid ethyl ester, 9, 12\u2010octadecadienoic acid ethyl ester, octadecanoic acid ethyl ester, 9\u2010octadecenoic acid ethyl ester and diethyl phthalate as the main compounds present in<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>. We also demonstrated<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>kills promastigotes and amastigotes in vitro and significantly reduces parasite loads in liver and spleen of infected Balb\/c mice.<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>induces expression of<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>kB\/<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u20101 transcription factors and production of<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 and<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 by spleen cells of<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>treated but not in the untreated control mice. Furthermore, there were not<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 nor<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>production in macrophages treated in vitro with<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>. We developed an affordable extract of<jats:italic>P.\u00a0andrieuxii<\/jats:italic>effective to treat experimental Kala\u2010azar in Balb\/c mice.<\/jats:p>","DOI":"10.1111\/pim.12495","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T13:42:45Z","timestamp":1507297365000},"source":"Crossref","is-referenced-by-count":2,"title":["Treating murine Kala\u2010azar with a Mayan plant induces immunochemical changes"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-5287","authenticated-orcid":false,"given":"C. 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