{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:21:44Z","timestamp":1762867304762,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Humoral immunity wanes during healthy ageing, increasing susceptibility to infections in the elderly. In this sense, information about parasite infections and human immunosenescence is scarce. Cystic echinococcosis (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) is an infectious disease caused by the larval stage of the cestode parasite <jats:italic>Echinococcus granulosus<\/jats:italic>, whose prevalence in humans shows an increase with host age. Susceptibility to human <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> has been associated with humoral immunity to some extent, and, therefore, we have here analysed the influence of host age on the serological profile of young, middle\u2010aged and aged patients. Our results highlighted the detrimental influence of ageing on the intensity and quality of the antiparasite antibody response. Remarkable differences in serological profiles between young and aged individuals were observed. In this sense, through Principal Components Analysis, we identified aged patients as those exhibiting overall less intense antibody responses, mainly in isotypes\/subclasses supposed to exert efficient antiparasite activities (eg IgE and IgG1). Thus, these humoral defects could at least partially explain the reported increase in <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> prevalence among older individuals, as a weaker immune response in the elderly might facilitate the establishment and maintenance of the parasite infection. Finally, a possible association between age\u2010dependent susceptibility to <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> and host immunosenescence is discussed.<\/jats:p>","DOI":"10.1111\/pim.12505","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T17:02:41Z","timestamp":1511283761000},"source":"Crossref","is-referenced-by-count":5,"title":["Ageing impairs parasite\u2010specific antibody responses in cystic echinococcosis"],"prefix":"10.1111","volume":"40","author":[{"given":"G.","family":"Mourglia\u2010Ettlin","sequence":"first","affiliation":[{"name":"\u00c1rea Inmunolog\u00eda Facultad de Qu\u00edmica\/Facultad de Ciencias DEPBIO\/IQB Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Miles","sequence":"additional","affiliation":[{"name":"\u00c1rea Inmunolog\u00eda Facultad de Qu\u00edmica\/Facultad de Ciencias DEPBIO\/IQB Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"\u00c1rea Inmunolog\u00eda Facultad de Qu\u00edmica\/Facultad de Ciencias DEPBIO\/IQB Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-2444","authenticated-orcid":false,"given":"S.","family":"Dematteis","sequence":"additional","affiliation":[{"name":"\u00c1rea Inmunolog\u00eda Facultad de Qu\u00edmica\/Facultad de Ciencias DEPBIO\/IQB Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2008.03.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/639362"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.58.599"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.462"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2008.10.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2010.06.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0692"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-9957-3-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2014.08.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"e0004154","DOI":"10.1371\/journal.pntd.0004154","article-title":"Surveillance of Human Echinococcosis in Castilla\u2010Leon (Spain) between 2000\u20102012","volume":"9","author":"L\u00f3pez\u2010Bernus A","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.02.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001714"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(96)00637-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.2000.11813546"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1997.d01-173.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01925.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12302"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0308-303"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8289-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2015.05.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12326"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12054"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/425014"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.07.009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.07.007"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:18:40Z","timestamp":1695993520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/pim.12505"],"URL":"https:\/\/doi.org\/10.1111\/pim.12505","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"type":"print","value":"0141-9838"},{"type":"electronic","value":"1365-3024"}],"subject":[],"published":{"date-parts":[[2017,12,4]]},"article-number":"e12505"}}