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The profile of<jats:italic>T.\u00a0vaginalis\u2010<\/jats:italic>specific antibodies and T cell\u2013mediated immune responses may influence the outcome of infection, towards parasite elimination, persistence or pathological reactions. Studies have indicated that Th1\u2010, Th17\u2010 and Th22 cell\u2010related cytokines may be protective or pathogenic, whereas Th2\u2010 and Treg cell\u2010related cytokines can exert anti\u2010inflammatory effects during<jats:italic>T.\u00a0vaginalis<\/jats:italic>infection. A number of<jats:italic>T.\u00a0vaginalis<\/jats:italic>\u2010related components such as lipophosphoglycan (Tv<jats:styled-content style=\"fixed-case\">LPG<\/jats:styled-content>), \u03b1\u2010actinin, migration inhibitory factor (Tv<jats:styled-content style=\"fixed-case\">MIF<\/jats:styled-content>), pyruvate:ferredoxin oxidoreductase (<jats:styled-content style=\"fixed-case\">PFO<\/jats:styled-content>), legumain\u20101 (Tv<jats:styled-content style=\"fixed-case\">LEGU<\/jats:styled-content>\u20101), adhesins and cysteine proteases lead to the induction of specific antibodies.<jats:italic>T.\u00a0vaginalis<\/jats:italic>has acquired several strategies to evade the humoral immune responses such as degradation of immunoglobulins by cysteine proteases, antigenic variation and killing of antibody\u2010producing B cells. The characterization of the<jats:italic>T.\u00a0vaginalis<\/jats:italic>\u2010specific antibodies to significant immunogenic molecules and formulation of strategies to promote their induction in vaginal mucosa may reveal their potential protective effects against trichomoniasis. In this\u00a0review, we discuss the current understanding of antibody and T cell\u2013mediated immune responses to<jats:italic>T.\u00a0vaginalis<\/jats:italic>and highlight novel insights into the possible role of immune\u00a0responses in protection against parasite.<\/jats:p>","DOI":"10.1111\/pim.12510","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T13:36:34Z","timestamp":1513776994000},"source":"Crossref","is-referenced-by-count":35,"title":["Humoral and T cell\u2013mediated immune response against trichomoniasis"],"prefix":"10.1111","volume":"40","author":[{"given":"M.","family":"Nemati","sequence":"first","affiliation":[{"name":"Department of Immunology School of Medicine Kerman University of Medical Sciences Kerman Iran"},{"name":"Department of Laboratory Sciences School of Para\u2010Medicine Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Malla","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Dr. B. 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