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Natural Killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells can be directly invaded by the parasite and this invasion alters <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell migration, producing a hypermotile phenotype. However, the consequences of this hypermotile phenotype for the dissemination of <jats:italic>T.\u00a0gondii<\/jats:italic> to the brain remain unknown. To address this, C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>6\/J mice were infected with freshly egressed tachyzoites (type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content><jats:italic>Prugniaud<\/jats:italic> strain) or with parasitized <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells. Under both conditions, parasite loads in the brain were comparable, indicating that parasitized <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells were not able to facilitate spread of <jats:italic>T.\u00a0gondii<\/jats:italic> to the brain. Consistent with this, we found no evidence for the recruitment of endogenous <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells to the brain at early time points post\u2010infection, nor any changes in the expression of \u03b14\u03b21 integrin, involved in recruitment of <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells to the brain. We therefore found no evidence for a role for hypermotile <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells in delivery of parasites to the brain during acute infection with <jats:italic>T.\u00a0gondii<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pim.12522","type":"journal-article","created":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T10:52:37Z","timestamp":1519555957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Parasitized Natural Killer cells do not facilitate the spread of <i>Toxoplasma gondii<\/i> to the brain"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-6497","authenticated-orcid":false,"given":"L.","family":"Petit\u2010Jentreau","sequence":"first","affiliation":[{"name":"Department of Infection Biology Institute of Infection and Global Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Glover","sequence":"additional","affiliation":[{"name":"Department of Infection Biology Institute of Infection and Global Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-9951","authenticated-orcid":false,"given":"J. 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