{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:09:07Z","timestamp":1761311347279,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["181175"],"award-info":[{"award-number":["181175"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Diagnostic tests for toxoplasmosis are based on serological techniques due to their high sensitivity. Some IgG subclasses are related to clinical outcome in the congenital form. In this work, we determined the levels of IgG, IgA, IgG1, IgG2, IgG3 and IgG4 anti\u2010<jats:italic>Toxoplasma gondii<\/jats:italic> antibodies in paired saliva and serum samples from 91 women by indirect <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> using a crude extract of the <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> strain. The levels of IgA, IgG2, IgG3 and IgG4 antibodies and, to a lesser extent, IgG1 did not correlate between saliva and serum, that is, most cases that were positive for one Ig class in a sample were negative or very low in the other, and vice versa. We also observed that most samples of saliva that were positive for one IgG subclass were also positive for at least 2 of the other 3; this contrasted with findings in serum, wherein each person was positive almost exclusively for one subclass, as demonstrated before by us and other researchers. Although these findings are disappointing for the use in diagnosis, the richer response in saliva might indicate local exposure to <jats:italic>T.\u00a0gondii<\/jats:italic> antigens without systemic infection; thus, saliva might be reflecting a local (protective?) response against this protozoan.<\/jats:p>","DOI":"10.1111\/pim.12526","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T23:41:33Z","timestamp":1521934893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["What do anti\u2010<i>Toxoplasma gondii<\/i> IgA and IgG subclasses in human saliva indicate?"],"prefix":"10.1111","volume":"40","author":[{"given":"I.","family":"Ca\u00f1edo\u2010Solares","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Experimental Subdirecci\u00f3n de Medicina Experimental Instituto Nacional de Pediatr\u00eda, Secretar\u00eda de Salud  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-2143","authenticated-orcid":false,"given":"F.","family":"G\u00f3mez\u2010Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Experimental Subdirecci\u00f3n de Medicina Experimental Instituto Nacional de Pediatr\u00eda, Secretar\u00eda de Salud  Ciudad de M\u00e9xico M\u00e9xico"},{"name":"C\u00e1tedras CONACyT Instituto Nacional de Pediatr\u00eda  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Luna\u2010Past\u00e9n","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Experimental Subdirecci\u00f3n de Medicina Experimental Instituto Nacional de Pediatr\u00eda, Secretar\u00eda de Salud  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Ortiz\u2010Alegr\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Experimental Subdirecci\u00f3n de Medicina Experimental Instituto Nacional de Pediatr\u00eda, Secretar\u00eda de Salud  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Flores\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Experimental Subdirecci\u00f3n de Medicina Experimental Instituto Nacional de Pediatr\u00eda, Secretar\u00eda de Salud  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Figueroa\u2010Dami\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda e Inmunolog\u00eda Instituto Nacional de Perinatolog\u00eda, Secretar\u00eda de Salud  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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