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Previous studies have revealed that <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>30 has an immunoregulatory effect, but the underlying mechanism for this effect remains unknown. This study shows that <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>30 induces dendritic cell (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>) maturation and increases the production of pro\u2010inflammatory cytokines. The expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86 and <jats:styled-content style=\"fixed-case\">MHC II<\/jats:styled-content> was upregulated in <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s following stimulation with <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>30 in vitro. Moreover, <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>30 induced Th17 polarization by increasing the production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2. In vivo, Th17 differentiation was induced by the production of key pro\u2010inflammatory cytokines, including <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2, from <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s of <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>30\u2010immunized mice. These results indicate that <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>30 promotes Th17 polarization through <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> activation, preventing serious schistosomiasis.<\/jats:p>","DOI":"10.1111\/pim.12528","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:23:16Z","timestamp":1522027396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>NP<\/scp>30 stimulates Th17 differentiation through <scp>DC<\/scp> in <i>Schistosomiasis Japonicum<\/i>"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5586-6851","authenticated-orcid":false,"given":"L.","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology Nanjing Medical University  Nanjing China"},{"name":"The Key Laboratory of Antibody Technique of Ministry of Health Nanjing Medical 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