{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:48:17Z","timestamp":1783777697316,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To explore <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010\u03b3 and <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>\u20102 transcription factors expression in placenta according to maternal anti\u2010<jats:italic>Toxoplasma gondii<\/jats:italic> serological profile during pregnancy and pregnancy outcome. The study included 240 placentas, grouped according to IgM and IgG serostatus and then subgrouped according to pregnancy outcome that varied between miscarriages, premature labour, stillbirth and giving birth to <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> anomaly or apparently healthy neonates. Samples were H&amp;E stained and histopathologically scored blindly. <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010\u03b3 expression was measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>, while <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>\u20102\u2010positive nuclei were stained immunohistochemically to be calculated by ImageJ. The mean pathological score was significantly higher in IgM+ve and IgG rising than IgG\u2010ve and persistent low groups. Former groups showed significantly higher <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010\u03b3 (mean\u00a0=\u00a0258.63, 227.11). However, <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010\u03b3 was higher in apparently healthy neonate subgroups. <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>\u20102 was significantly lower in IgM+ve and IgG rising groups (mean\u00a0=\u00a012.87, 43.13) and associated with obvious fibrosis. <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>\u20102 lowest count was in <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> anomaly subgroup. <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010\u03b3 and <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>\u20102 changes may give clues of how <jats:italic>Toxoplasma<\/jats:italic> induces pathogenesis during vertical transmission. Triggering <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010\u03b3 expression may be a tool to downregulate the inflammatory response and establish a metabolically permissive cellular environment for <jats:italic>Toxoplasma<\/jats:italic> persistence. Low <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>\u20102 is suspected to disturb placental mesenchymal stem cells pluripotency and neuroectoderm development.<\/jats:p>","DOI":"10.1111\/pim.12529","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T08:21:44Z","timestamp":1522052504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Human placental <scp>PPAR<\/scp>\u2010\u03b3 and <scp>SOX<\/scp>\u20102 expression in serologically proved toxoplasmosis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5972-5773","authenticated-orcid":false,"given":"M.","family":"Hasby Saad","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine Tanta University  Tanta 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