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The rapid expulsion of <jats:italic>T.\u00a0muris<\/jats:italic> in resistant mouse strains is associated with the induction of a protective T helper cell type 2 (Th2)\u2010polarized immune response. Susceptible mouse strains, in contrast, mount an inappropriate Th1 response to <jats:italic>T.\u00a0muris<\/jats:italic> infection. Expression of the chemokine <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>13 by stromal follicular dendritic cells attracts <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5\u2010expressing cells towards the B\u2010cell follicles. Previous studies using a complex in vivo depletion model have suggested that <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5\u2010expressing conventional dendritic cells (<jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content>) help regulate the induction of Th2\u2010polarized responses. Here, transgenic mice with <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5 deficiency specifically restricted to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c<jats:sup>+<\/jats:sup> cells were used to determine whether the specific absence <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5 on <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c<jats:sup>+<\/jats:sup> cells such as <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content> would influence susceptibility to oral <jats:italic>T.\u00a0muris<\/jats:italic> infection by affecting the Th1\/Th2 balance. We show that in contrast to control mice, those which lacked <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5 expression on <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c<jats:sup>+<\/jats:sup> cells failed to clear <jats:italic>T.\u00a0muris<\/jats:italic> infection and developed cytokine and antibody responses that suggested a disturbed Th1\/Th2 balance with enhanced <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 expression. These data suggest an important role of <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5\u2010expressing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c<jats:sup>+<\/jats:sup> cells such as <jats:styled-content style=\"fixed-case\">cDC<\/jats:styled-content> in immunity to oral <jats:italic>T.\u00a0muris<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/pim.12566","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T19:13:00Z","timestamp":1529435580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased susceptibility to oral <i>Trichuris muris<\/i> infection in the specific absence of <scp>CXCR<\/scp>5<sup>+<\/sup><scp>CD<\/scp>11c<sup>+<\/sup> cells"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-1685","authenticated-orcid":false,"given":"Barry M.","family":"Bradford","sequence":"first","affiliation":[{"name":"The Roslin Institute &amp; Royal (Dick) School of Veterinary Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Donaldson","sequence":"additional","affiliation":[{"name":"The Roslin Institute &amp; Royal (Dick) School of Veterinary Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Forman","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn J.","family":"Else","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-1796","authenticated-orcid":false,"given":"Neil A.","family":"Mabbott","sequence":"additional","affiliation":[{"name":"The Roslin Institute &amp; Royal (Dick) School of Veterinary Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.22"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.1036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.04.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2679"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091627"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091756"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.347"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.4049\/jimmunol.160.7.3453","article-title":"A critical role for IL\u201013 in resistance to intestinal nematode infection","volume":"160","author":"Bancroft AJ","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.8.3832-3840.1998"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.767"},{"key":"e_1_2_8_16_1","first-page":"232","article-title":"Cellular immune responses to the murine nematode parasite Trichuris muris. 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