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This protection translated into a 65.5% mean reduction in adult worm burden after a homologous challenge, and a significant decrease (73.2%) in cumulative faecal egg counts (<jats:styled-content style=\"fixed-case\">FEC<\/jats:styled-content>s). These parasitological findings were consistent with the levels of some biopathological parameters. Thus, the reduction in adult worms and <jats:styled-content style=\"fixed-case\">FEC<\/jats:styled-content> observed in immunized animals were associated with increased levels of packed cell volume as well as plasma proteins. This response seems to be related to an important increase in specific antibodies (in serum and gastric mucus) and eosinophilia in response to challenge. At the local level, a cellular response was also observed in which CD4<jats:sup>+<\/jats:sup> lymphocytes and globule leucocytes played a predominant role. Finally, it should be noted that the study of immunolocalization of proteins used in the vaccination trial suggests that these antigens have an internal location (at intestinal and reproductive tissues) in the adult worm. This observation, in conjunction with the kinetics of specific antibody levels after the challenge, suggests that these antigens may be part of excretory\/secretory (E\/S) products.<\/jats:p>","DOI":"10.1111\/pim.12569","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T06:00:37Z","timestamp":1530338437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immune response in goats vaccinated with thiol\u2010binding proteins from <i>Haemonchus contortus<\/i>"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-2512","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Molina","sequence":"first","affiliation":[{"name":"Department of Animal Pathology Faculty of Veterinary Medicine University of Gran Canaria  Gran Canaria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeray 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