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As C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) can act as an innate receptor with ability to bind the phosphocholine moiety of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in lipoproteins, we investigated whether EgAgB and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> could interact during cystic echinococcosis infection (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>), and how <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> binding could affect the modulation activities exerted by EgAgB on macrophages. To that end, we firstly investigated the occurrence of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> induction during human <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>. We found that 61% of <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> patients, but none of healthy donors, exhibited serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels higher than 10\u00a0mg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, suggesting that <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> can be induced during the chronic phase of <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>. Furthermore, human <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was capable of binding specifically to EgAgB with high affinity (0.6\u00a0\u00b1\u00a00.1 <jats:styled-content style=\"fixed-case\">nM<\/jats:styled-content>); this binding was Ca<jats:sup>2+<\/jats:sup>\u2010dependent and involved the phosphocholine moiety of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>, but not EgAgB8\/1, EgAgB8\/2 or EgAgB8\/3 apolipoproteins. Finally, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> presence altered the modulation exerted by EgAgB on the cytokine response of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010activated macrophages. Overall, our results suggest that <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> presence during <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> may contribute to a complex scenario of interactions between EgAgB and myeloid cells, influencing the cytokine response induced during macrophage activation.<\/jats:p>","DOI":"10.1111\/pim.12575","type":"journal-article","created":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T15:48:45Z","timestamp":1532188125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antigen B from <i>Echinococcus granulosus<\/i> is a novel ligand for C\u2010reactive protein"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-3823","authenticated-orcid":false,"given":"Valeria","family":"Silva\u2010\u00c1lvarez","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Inmunolog\u00eda Facultad de 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