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However, little is known about the role of the nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) mediator, induced by the enzyme nitric oxide synthase (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>), in strongyloidiasis. Therefore, in this study, we investigated the immune response of mice genetically deficient in the enzyme inducible nitric oxide synthase (<jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup>), infected with <jats:italic>Strongyloides venezuelensis<\/jats:italic>. C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> mice were individually inoculated by subcutaneous injection of 3000 <jats:italic>S.\u00a0venezuelensis<\/jats:italic> L3 larvae. In the absence of <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>, mice were more susceptible to the infection than <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> animals, in which the parasite was completely eliminated. The overall production of cytokines and specific IgG, IgG1 or IgE antibodies against the parasite was significantly lowered in infected <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> mice. The expression of <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content> was observed in the intestine of <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> hosts but mainly in the wall of the parasite, despite the presence of <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content> in mice. Altogether, we concluded that <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content> expression may play an important role in the control of <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>venezuelensis<\/jats:italic> infection.<\/jats:p>","DOI":"10.1111\/pim.12576","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T10:48:46Z","timestamp":1532342926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inducible nitric oxide synthase controls experimental <i>Strongyloides<\/i> infection"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-3649","authenticated-orcid":false,"given":"Ros\u00e2ngela Maria","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Parasitologia Universidade Federal de Goi\u00e1s  Regional Jata\u00ed GO 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