{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:50:48Z","timestamp":1777344648423,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["17ZR1433300"],"award-info":[{"award-number":["17ZR1433300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late\u2010stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflected by dysfunctional, auto\u2010reactive antibodies. Antinuclear antibodies (ANA) have been reported in schistosomiasis due to <jats:italic>S.\u00a0mansoni<\/jats:italic> and <jats:italic>S.\u00a0haematobium<\/jats:italic>. We demonstrate ANA in schistosomiasis japonica and explore the relationship between this infection and autoimmune disease by measuring ANA and interleukin (IL)\u201010, IL\u201012 and IL\u201017 responses in the sera of 125 Chinese patients with different stages of schistosomiasis japonica. The incidence rates of ANA in the patients with acute, chronic and late stages of schistosomiasis infection were 6.7%, 23.3% and 70.0%, respectively, with statistically significant differences between each stage (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000). IL\u201017 concentrations were high at the acute stage of schistosomiasis compared to the other stages of the disease (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000). This pattern was also seen for IL\u201010 and IL\u201012 concentrations (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01). IL concentrations in patients in the chronic and late stages of the disease were low and showed no difference compared to the healthy adults.<\/jats:p>","DOI":"10.1111\/pim.12577","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T05:15:28Z","timestamp":1533618928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antinuclear antibodies and interleukin responses in patients with <i>Schistosoma japonicum<\/i> infection"],"prefix":"10.1111","volume":"40","author":[{"given":"Xiang","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Biology and Medical Sciences Soochow University  Suzhou China"},{"name":"Key Laboratory of Molecular Virology &amp; Immunology Vaccine Research Center Institut Pasteur of Shanghai, Chinese Academy of Sciences  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Fu","sequence":"additional","affiliation":[{"name":"RenjiHospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Song","sequence":"additional","affiliation":[{"name":"RenjiHospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Virology &amp; Immunology Vaccine Research Center Institut Pasteur of Shanghai, Chinese Academy of Sciences  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bergquist","sequence":"additional","affiliation":[{"name":"Ingerod  Brastad Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Parasite and Vector Biology, Ministry of Health National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizhu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Parasite and Vector Biology, Ministry of Health National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Virology &amp; Immunology Vaccine Research Center Institut Pasteur of Shanghai, Chinese Academy of Sciences  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1130-4689","authenticated-orcid":false,"given":"Zhiqiang","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Parasite and Vector Biology, Ministry of Health National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO 2017 WHO Geneva Switzerland"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"e_1_2_10_4_1","volume-title":"The Biology and Life Cycle of Schistosoma","author":"CDC","year":"2012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12087"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-017-0335-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01409-X"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4091438"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60434-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00789.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1799-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000247591.13671.6a"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2014.06.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.02.015"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/20014091111893"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.08.049"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(00)00125-X"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.08.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.05.027"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939409014668"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309345735"},{"issue":"2","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1128\/iai.32.2.438-442.1981","article-title":"Thymocytotoxic autoantibodies found in mice infected with Schistosoma japonicum","volume":"32","author":"Kawabata M","year":"1981","journal-title":"Infect Immun"},{"issue":"2","key":"e_1_2_10_25_1","first-page":"230","article-title":"Autoantibodies to intermediate filaments in sera of patients with Schistosoma mansoni infection","volume":"77","author":"Boehme MW","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1601"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/264173"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019149"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(89)90006-1"},{"issue":"1","key":"e_1_2_10_30_1","first-page":"289","article-title":"A study of autoimmunity in schistosomiasis","volume":"23","author":"Abbas MM","year":"1993","journal-title":"J Egypt Soc Parasitol"},{"issue":"4","key":"e_1_2_10_31_1","first-page":"353","article-title":"Evaluation of auto\u2010antibody to DNA and soluble immune complexes in children with urinary schistosomiasis","volume":"31","author":"Arinola OG","year":"2002","journal-title":"Afr J Med Med Sci"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001399"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141933"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12105"},{"issue":"2","key":"e_1_2_10_35_1","first-page":"189","article-title":"Schistosoma japonicum soluble egg antigens activate naive B cells to produce antibodies: definition of parasite mechanisms of immune deviation","volume":"79","author":"Yamashita T","year":"1993","journal-title":"Immunology"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2011.5.3.340"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13317-016-0075-0"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1309\/MV9RM1FDLWAUWQ3F"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.05.007"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.06.019"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231780"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652408785160998"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-009-9188-9"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"issue":"4","key":"e_1_2_10_46_1","first-page":"249","article-title":"Helminths and autoimmunity: the good, the bad and the ugly","volume":"17","author":"Versini M","year":"2015","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20633"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8352-9"},{"issue":"1","key":"e_1_2_10_50_1","first-page":"8","article-title":"The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases\u20132008","volume":"10","author":"Shoenfeld Y","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.12.005"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091903"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.12.002"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T12:31:16Z","timestamp":1694953876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/pim.12577"],"URL":"https:\/\/doi.org\/10.1111\/pim.12577","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]},"assertion":[{"value":"2017-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12577"}}