{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:01:55Z","timestamp":1778284915973,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T00:00:00Z","timestamp":1537056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic helminth infection with <jats:italic>Schistosoma (S.) mansoni<\/jats:italic> protects against allergic airway inflammation (<jats:styled-content style=\"fixed-case\">AAI<\/jats:styled-content>) in mice and is associated with reduced Th2 responses to inhaled allergens in humans, despite the presence of schistosome\u2010specific Th2 immunity. Schistosome eggs strongly induce type 2 immunity and allow to study the dynamics of Th2 versus regulatory responses in the absence of worms. Treatment with isolated <jats:italic>S.\u00a0mansoni<\/jats:italic> eggs by i.p. injection prior to induction of <jats:styled-content style=\"fixed-case\">AAI<\/jats:styled-content> to ovalbumin (<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>)\/alum led to significantly reduced <jats:styled-content style=\"fixed-case\">AAI<\/jats:styled-content> as assessed by less <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content> and lung eosinophilia, less cellular influx into lung tissue, less <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010specific Th2 cytokines in lungs and lung\u2010draining mediastinal lymph nodes and less circulating allergen\u2010specific IgG1 and IgE antibodies. While <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010specific Th2 responses were inhibited, treatment induced a strong systemic Th2 response to the eggs. The protective effect of <jats:italic>S.\u00a0mansoni<\/jats:italic> eggs was unaltered in \u03bc<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> mice lacking mature (B2) B cells and unaffected by Treg cell depletion using anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 blocking antibodies during egg treatment and allergic sensitization. Notably, prophylactic egg treatment resulted in a reduced influx of pro\u2010inflammatory, monocyte\u2010derived dendritic cells into lung tissue of allergic mice following challenge. Altogether, <jats:italic>S.\u00a0mansoni<\/jats:italic> eggs can protect against the development of <jats:styled-content style=\"fixed-case\">AAI<\/jats:styled-content>, despite strong egg\u2010specific Th2 responses.<\/jats:p>","DOI":"10.1111\/pim.12579","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T21:07:01Z","timestamp":1534280821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Isolated <i>Schistosoma mansoni<\/i> eggs prevent allergic airway inflammation"],"prefix":"10.1111","volume":"40","author":[{"given":"Katja","family":"Obieglo","sequence":"first","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn J.","family":"Schuijs","sequence":"additional","affiliation":[{"name":"Immunoregulation and Mucosal Immunology VIB Inflammation Research Center  Ghent Belgium"},{"name":"Department of Internal Medicine Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arifa","family":"Ozir\u2010Fazalalikhan","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"van Wijck","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Boon","sequence":"additional","affiliation":[{"name":"Bioceros  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Immunoregulation and Mucosal Immunology VIB Inflammation Research Center  Ghent Belgium"},{"name":"Department of Internal Medicine Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Taube","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermelijn H.","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"PawankarR CanonicaGW HolgateST LockeyRF BlaissM.The WAO White Book on Allergy. 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