{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:13:08Z","timestamp":1777648388122,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed at investigating the presence of intestinal parasitic infections in inflammatory respiratory diseases patients during the disease attack, and measuring the acidic mammalian chitinase (AMCase) gene expression in blood before and after infection eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This case\u2010control study included 123 inflammatory respiratory diseases patients and 120 apparently healthy individuals. Repeated stool examination was done, while total and specific IgE were measured. <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>ase gene expression was analysed by real time\u2010polymerase chain reaction (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infection was detected in 32.5% of the diseased and 23.25% of the healthy individuals. Higher rate of the helminthic infection was detected (23.57) in comparison to the protozoal (12.19%) in the patients. A significantly higher rate of infection with the chitin\u2010rich helminths \u201cEnterobius vermicularis &amp; Hymenolepis nana\u201d and level of anti\u2010Dermatophagoide\u2010IgE were reported in the patients (14.63%, 6.5% and 23.57%, respectively). <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>ase expression was significantly higher in helminths\u2010infected patients than the noninfected, or protozoa infected. After infection eradication, <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>ase expression significantly declined in the previously helminth\u2010infected patients (mean \u00b1 SD\u00a0=\u00a013.9\u00a0\u00b1\u00a03.918 before and 4.515\u00a0\u00b1\u00a01.93 after), but insignificantly affected in the protozoa infected (mean \u00b1 SD\u00a0=\u00a02.095\u00a0\u00b1\u00a0.285 before and 2.675\u00a0\u00b1\u00a01.181 after).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chitin\u2010rich intestinal helminths are suspected to precipitate Th2\u2010immune response in remote tissues by enhancing systemic <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>ase expression through intestinal mucosa and macrophages irritation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pim.12583","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T07:50:37Z","timestamp":1534492237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acidic mammalian chitinase tuning after enteric helminths eradication in inflammatory respiratory disease patients"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5972-5773","authenticated-orcid":false,"given":"Marwa A.","family":"Hasby Saad","sequence":"first","affiliation":[{"name":"Medical Parasitology Department Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Watany","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Tanta University  Tanta 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