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Here, we discuss findings of studies done of the effects of <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> parasites on atopy and allergic diseases in Ecuador. While cross\u2010sectional studies have consistently shown a reduced prevalence of allergen skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) reactivity among infected schoolchildren, the removal of these infections by repeated deworming did not affect <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> prevalence over the short\u2010term (ie, 12\u00a0months) but may have increased <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> prevalence over the long\u2010term (ie, 15\u201017\u00a0years). In the case of allergic symptoms, cross\u2010sectional studies have generally not shown associations with <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> and intervention studies showed no impact on prevalence. However, a birth cohort suggested that early <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> infections might reduce wheeze by 5\u00a0years. Allergic sensitization to <jats:italic>Ascaris<\/jats:italic>, however, explained a significant proportion of wheezing among rural schoolchildren. Studies of the effects of <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> on immune and inflammatory responses indicated a potential role of <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> in contributing to more robust regulation. The effects of <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> on allergy are likely to be determined by history of exposure over the life\u2010course and by interactions with a wide variety of other infectious and non\u2010infectious factors.<\/jats:p>","DOI":"10.1111\/pim.12590","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T11:44:13Z","timestamp":1537357453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Soil\u2010transmitted helminth parasites and allergy: Observations from Ecuador"],"prefix":"10.1111","volume":"41","author":[{"given":"Martha E.","family":"Chico","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Ecuatoriana Para Investigaci\u00f3n en Salud  Quito Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maritza G.","family":"Vaca","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Ecuatoriana Para Investigaci\u00f3n en Salud  Quito Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Ecuatoriana Para Investigaci\u00f3n en Salud  Quito Ecuador"},{"name":"Faculty of Epidemiology and Population Health London School of Hygiene and Tropical Medicine  London UK"},{"name":"Facultad de Ciencias Medicas, de la Salud y la Vida Universidad Internacional del Ecuador  Quito Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-6871","authenticated-orcid":false,"given":"Philip J.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Ecuatoriana Para Investigaci\u00f3n en Salud  Quito Ecuador"},{"name":"Facultad de Ciencias Medicas, de la Salud y la Vida Universidad Internacional del Ecuador  Quito Ecuador"},{"name":"Institute of Infection and Immunity St George's University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036285"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(84)80012-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236167"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00615.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90119-Z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90067-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-331OC"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02512.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"e_1_2_9_12_1","unstructured":"World health Assembly.Schistosomiasis and soil\u2010transmitted helminths.http:\/\/www.who.int\/neglected_diseases\/mediacentre\/WHA_54.19_Eng.pdf. 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