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Schistosoma mansoni<\/jats:italic>\u2010infected individuals were recruited from a schistosomiasis endemic area in Uganda (n\u00a0=\u00a0372), treated with 40\u00a0mg\/kg praziquantel (PZQ<\/jats:styled-content>) and followed up at five weeks and at one year post\u2010treatment. Pre\u2010treatment and five weeks post\u2010treatment immunoglobulin (Ig) E, IgG1 and IgG4 levels against recombinant schistosomula antigens rSmKK<\/jats:styled-content>7, rSmL<\/jats:styled-content>y6A, rSmL<\/jats:styled-content>y6B and rSmTSP<\/jats:styled-content>7 were measured using ELISA<\/jats:styled-content>. Factors associated with detectable pre\u2010treatment or post\u2010treatment antibody response against the schistosomula antigens and the association between five\u2010week antibody responses and one year post\u2010treatment reinfection intensity among antibody responders were examined. Being male was associated with higher pre\u2010treatment IgG1 to rSmKK<\/jats:styled-content>7, rSmL<\/jats:styled-content>y6a and AWA<\/jats:styled-content>. Five weeks post\u2010treatment antibody responses against schistosomula antigens were not associated with one year post\u2010treatment reinfection intensity among antibody responders\u2019 antibody levels against rSmKK<\/jats:styled-content>7, rSmL<\/jats:styled-content>y6B and rSmTSP<\/jats:styled-content>7 dropped, but increased against rSmL<\/jats:styled-content>y6A, AWA<\/jats:styled-content> and SEA<\/jats:styled-content> at five weeks post\u2010treatment among antibody responders. S.\u00a0mansoni<\/jats:italic>\u2010infected individuals exhibit detectable antibody responses to schistosomula antigens that are affected by treatment. These findings indicate that schistosomula antigens induce highly varied antibody responses and could have implications for vaccine development.<\/jats:p>","DOI":"10.1111\/pim.12591","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T23:04:39Z","timestamp":1537571079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antibody responses to Schistosoma mansoni<\/i> schistosomula antigens"],"prefix":"10.1111","volume":"40","author":[{"given":"Moses","family":"Egesa","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology School of Biomedical Sciences Makerere University College of Health Sciences Kampala Uganda"},{"name":"Medical Research Council\/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit Entebbe 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