{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:07:11Z","timestamp":1790777231994,"version":"4.1.0"},"reference-count":116,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["515\u20102012"],"award-info":[{"award-number":["515\u20102012"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["590\u20102013"],"award-info":[{"award-number":["590\u20102013"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and the same effects have been detected on the underlying immune responses. In this review we analyze the work on this field performed in Colombia, a Latin American tropical country, including aspects such as the molecular genetics of the IgE response to Ascaris; the allergenic activity of Ascaris IgE\u2010binding molecular components and the immunological and clinical influences of ascariasis on asthma. The analysis allows us to conclude that the impact of ascariasis on the inception and evolution of allergic diseases such as asthma deserves more investigation, but advances have been made during the last years. The concurrent parasite\u2010induced immunostimulatory and immunosuppressive effects during this helminthiasis do modify the natural history of asthma and some aspects of the practice of allergology in the tropics. Theoretically it can also influence the epidemiological trends of allergic diseases either by its absence or presence in different regions and countries.<\/jats:p>","DOI":"10.1111\/pim.12595","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T09:45:24Z","timestamp":1538991924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ascariasis as a model to study the helminth\/allergy relationships"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-1109","authenticated-orcid":false,"given":"Luis","family":"Caraballo","sequence":"first","affiliation":[{"name":"Institute for Immunological Research University of Cartagena  Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-2964","authenticated-orcid":false,"given":"Nathalie","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena  Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Zakzuk","sequence":"additional","affiliation":[{"name":"Institute for Immunological Research University of Cartagena  Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0110-7"},{"key":"e_1_2_7_3_1","unstructured":"OPS(2017)Salud en las Am\u00e9ricas Edici\u00f3n del 2017. 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