{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:23:48Z","timestamp":1780525428057,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our aim was to investigate the skin\u2010homing T\u2010cell immune responses triggered in patients with <jats:italic>Demodex<\/jats:italic> infestation and\/or rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with <jats:italic>Demodex<\/jats:italic> infestation (<jats:italic>Demodex<\/jats:italic> group); papulopustular rosacea (<jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content>) patients without <jats:italic>Demodex<\/jats:italic> infestation (Rosacea group); and <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> patients with <jats:italic>Demodex<\/jats:italic> infestation (Rosacea\/<jats:italic>Demodex<\/jats:italic> group). Following ex vivo activation, skin\u2010homing <jats:styled-content style=\"fixed-case\">CLA<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T\u2010cell subset levels were monitored by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared with control subjects, among skin\u2010homing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T\u2010cell subsets analysed, <jats:italic>Demodex<\/jats:italic> patients had higher <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>9 and T<jats:sub>reg<\/jats:sub> cell levels; Rosacea subjects displayed elevated <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>1 cell levels; and Rosacea\/<jats:italic>Demodex<\/jats:italic> patients exhibited increased frequencies of <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>9 and <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>22 cells. In contrast to Rosacea subjects, Rosacea\/<jats:italic>Demodex<\/jats:italic> group members displayed higher <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>2 cell levels; and when compared with <jats:italic>Demodex<\/jats:italic> groups, they had higher <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>2 but lower T<jats:sub>reg<\/jats:sub> cell levels. <jats:italic>Demodex<\/jats:italic> group members also exhibited higher T<jats:sub>reg<\/jats:sub> but lower <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">T<jats:sub>H<\/jats:sub><\/jats:styled-content>22 levels than Rosacea\/<jats:italic>Demodex<\/jats:italic> group subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The skin\u2010homing T\u2010cell responses associated with <jats:italic>Demodex<\/jats:italic> infestation and rosacea formation seem to influence each other. The present as well as future studies could contribute to the development of effective treatment strategies for demodicosis and rosacea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pim.12658","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T16:22:58Z","timestamp":1558714978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Skin\u2010homing T\u2010cell responses associated with <i>Demodex<\/i> infestation and rosacea"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-478X","authenticated-orcid":false,"given":"Umut","family":"Gazi","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Clinical Microbiology Faculty of Medicine Near East University Nicosia Northern Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse 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