{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:00:37Z","timestamp":1763535637926,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760371","81760570","81602810"],"award-info":[{"award-number":["81760371","81760570","81602810"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to investigate macrophage polarization during the early stages of secondary <jats:italic>Echinococcus granulosus<\/jats:italic> sensu lato (<jats:italic>E.\u00a0granulosus<\/jats:italic> s.l.) infection. We observed an early initial increase in inflammatory genes (peaking at 5\u201010\u00a0days) and a later rise in M (IL\u20104)\u2010like genes (still rising by day 15). In addition, we showed that the induction of M (IL\u20104)\u2010like genes was paralleled by an increase in expression of the transcription factor KLF4. Most of the changes observed <jats:italic>in vivo<\/jats:italic> were reproduced <jats:italic>in vitro<\/jats:italic> upon the culture of normal peritoneal macrophages with live <jats:italic>E.\u00a0granulosus<\/jats:italic> s.l. protoscoleces (PSC), and that knockdown of KLF4 in this system attenuates M (IL\u20104) differentiation. Our results suggest that KLF4 pathway contributes to the differentiation of macrophages towards M (IL\u20104)\u2010like phenotype during early stages of secondary <jats:italic>E.\u00a0granulosus<\/jats:italic> s.l. infection.<\/jats:p>","DOI":"10.1111\/pim.12666","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T12:28:58Z","timestamp":1565699338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["KLF4 upregulation is involved in alternative macrophage activation during secondary <i>Echinococcus granulosus<\/i> infection"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-2037","authenticated-orcid":false,"given":"Dan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Immunology School of Medicine Shihezi University Shihezi, Xinjiang 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