{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:57:04Z","timestamp":1788173824724,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["482113\/2010\u20103"],"award-info":[{"award-number":["482113\/2010\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Schistosomiasis affects about 240 million people worldwide and is estimated that about 700 million people live in areas at risk of infection. In the context of immune response associated with infection by <jats:italic>Schistosoma mansoni<\/jats:italic>, the role of memory T cells is not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the frequency of memory CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells from individuals resistant and susceptible to <jats:italic>Schistosoma mansoni<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We selected individuals with low (resistant) and high (susceptible) parasite burden using databases generated during previous studies carried out in the same endemic area. The cell surface markers were performed using flow cytometry. In this study, the resistant individuals showed an increase in the CD4<jats:sup>+<\/jats:sup> memory T\u2010cell pool associated with an increase in the central memory cell (TCM) and a decrease in the effector memory cell (T<jats:sub>EM<\/jats:sub>). Individuals susceptible to infection had higher frequencies of effector memory cells compared to resistant individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that resistance to <jats:italic>S\u00a0mansoni<\/jats:italic> infection may be associated with an increase in the number of CD4<jats:sup>+<\/jats:sup> memory T cells and susceptibility to infection is associated with a decrease in the central memory cell as well as high proportions of effector memory cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pim.12671","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T19:06:10Z","timestamp":1568833570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of memory T cells in individuals resistant to <i>Schistosoma mansoni<\/i> infection"],"prefix":"10.1111","volume":"41","author":[{"given":"Robson da Paix\u00e3o","family":"de Souza","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Imunologia Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ilma","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Mota","family":"Lopes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edsio Vila Verde Santana","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos Universidade Federal da Bahia Salvador Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady","family":"Page","sequence":"additional","affiliation":[{"name":"Tulane University School of Medicine New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Riccio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz Instituto Gon\u00e7alo Moniz Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos Universidade Federal da Bahia Salvador Brazil"},{"name":"Funda\u00e7\u00e3o Oswaldo Cruz Instituto Gon\u00e7alo Moniz Salvador Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais [INCT\u2010DT\u2010CNPQ\/MCT] Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-451X","authenticated-orcid":false,"given":"Luciana Santos","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Complexo Hospitalar Universit\u00e1rio Professor Edgard Santos Universidade Federal da Bahia Salvador Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais [INCT\u2010DT\u2010CNPQ\/MCT] Salvador Brazil"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia UFBA Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO (World Health Organization).Schistosomiasis.2019.https:\/\/www.who.int\/schistosomiasis\/disease\/en\/. Accessed March 10 2019."},{"key":"e_1_2_8_3_1","unstructured":"Brasil Minist\u00e9rio da Sa\u00fade.Esquistossomose: causas sintomas Tratamento diagn\u00f3stico e preven\u00e7\u00e3o.2019.http:\/\/portalms.saude.gov.br\/saude-de-a-z\/esquistossomose#epidemiologia. 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