{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:15:11Z","timestamp":1778847311268,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07529"],"award-info":[{"award-number":["19K07529"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25460523"],"award-info":[{"award-number":["25460523"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Many parasitic helminths are known to alter host immune responses and consequently affect the progression of autoimmune and allergic diseases. The parasitic nematode <jats:italic>Trichinella<\/jats:italic> sp has been reported to suppress several experimental diseases in rodents, including experimental autoimmune encephalomyelitis, type 1 diabetes, colitis, airway inflammation and autoimmune arthritis. We tried to clarify requirement of Th2 cytokines in the anti\u2010arthritic effects of <jats:italic>Trichinella spiralis<\/jats:italic> (Ts) against collagen\u2010induced arthritis (CIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We infected Ts and then induced CIA in STAT6KO DBA\/1 mice, comparing the disease progression with that in wild\u2010type (WT) DBA\/1 mice, Ts significantly mitigated arthritis in WT mice, in addition to the impairment of anti\u2013type II collagen (IIC) IgG production in a subclass\u2010independent manner. The genetic absence of STAT6 in the mice did not abrogate the anti\u2010arthritic effects of Ts. Alteration of splenic cytokines was not related to the anti\u2010arthritic effects of the parasite. Moreover, lack of IL\u201010 did not abrogate the anti\u2010arthritic effects of Ts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the anti\u2010arthritic effects of Ts do not require host Th2 signals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pim.12677","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T20:43:21Z","timestamp":1570913001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Th2 signals are not essential for the anti\u2010arthritic effects of <i>Trichinella spiralis<\/i> in mice"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-4807","authenticated-orcid":false,"given":"Yoshio","family":"Osada","sequence":"first","affiliation":[{"name":"Department of Immunology and Parasitology University of Occupational and Environmental Health Kitakyushu 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