{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:13:38Z","timestamp":1793279618705,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T00:00:00Z","timestamp":1579910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["Conselho Nacional de Desenvolvimento Cient\u00edfico e"],"award-info":[{"award-number":["Conselho Nacional de Desenvolvimento Cient\u00edfico e"]}],"id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    (\n                    <jats:italic>T gondii<\/jats:italic>\n                    ) infection has been associated with protection against allergy and autoimmune diseases. We investigated the effects of\n                    <jats:italic>T gondii<\/jats:italic>\n                    infection on cytokine and antibody responses in atopic and nonatopic Brazilian subjects. We have measured in whole\u2010blood cultures, Th1 (IFN\u2010\u03b3 and IL\u201012), Th2 (IL\u20105) and regulatory cytokine IL\u201010 in blood cells unstimulated and stimulated with pokeweed mitogen or\n                    <jats:italic>T gondii<\/jats:italic>\n                    soluble tachyzoites antigen (STAg) or\n                    <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>\n                    antigen. A significant negative association was found between high levels of anti\u2010dust mite IgE and\n                    <jats:italic>T gondii<\/jats:italic>\n                    seropositivity (OR\u00a0=\u00a00.46; 95%CI\u00a0=\u00a00.25\u20100.85). STAg stimulation induced a mixed profile of Th1 and Th2 cytokines (IFN\u2010\u03b3, IL\u201012 and IL\u20105) in Tg\u2010positive atopic individuals compared with Tg\u2010negative atopic individuals (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.0001,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.033 and\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.003, respectively). In contrast, IL\u201010 production was not different between these groups. No association was found between\n                    <jats:italic>T gondii<\/jats:italic>\n                    infection and asthma. We hypothesized that the protective effect on atopy might be related to the strong Th1 immune response to\n                    <jats:italic>T gondii<\/jats:italic>\n                    found on the seropositive subjects. From our knowledge, this is the first study to investigate the association between atopy and\n                    <jats:italic>T gondii<\/jats:italic>\n                    infection in Brazilian subjects, analysing the cellular immune responses.\n                  <\/jats:p>","DOI":"10.1111\/pim.12694","type":"journal-article","created":{"date-parts":[[2019,12,29]],"date-time":"2019-12-29T21:36:40Z","timestamp":1577655400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Toxoplasma gondii<\/i>\n                    protects from IgE sensitization and induces Th1\/Th2 immune profile"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1482-4241","authenticated-orcid":false,"given":"Milena M. C.","family":"Andrade","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-3362","authenticated-orcid":false,"given":"Valdirene L.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Vida Universidade do Estado da Bahia Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana A.","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-7791","authenticated-orcid":false,"given":"Thales R.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-0474","authenticated-orcid":false,"given":"Ricardo W. A.","family":"Vitor","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neuza Maria","family":"Alcantara\u2010Neves","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro A.","family":"Cruz","sequence":"additional","affiliation":[{"name":"ProAR \u2013 Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-6188","authenticated-orcid":false,"given":"Camila A.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Sa\u00fade Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03813.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-6-15"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1335"},{"key":"e_1_2_10_7_1","unstructured":"Signaling pathways in Th2 development \u2010 Mowen \u2010 2004 \u2010 Immunological Reviews \u2010 Wiley Online Library [Internet]. 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