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From each was collected peripheral blood\/EDTA for laboratory diagnosis. Blood cells for DNA extractions (molecular diagnosis), plasma for RNA extractions (gene expression) and ELISA (serological diagnosis). miRNA expression was performed by qPCR, and values were expressed in Relative Quantification (RQ). Among the five miRNAs, miR\u201021\u20105p and miR\u2010146a\u20105p were up\u2010expressed in CT\/HIV group when compared with AT and NC groups. RQ means for miR\u201021\u20105p and miR\u2010146a\u20105p in CT\/HIV group were 3.829 and 2.500, while in AT group, were 1.815 and 1.661, respectively. Differences between 3 groups were statistically significant (Kruskal\u2010Wallis ANOVA test), as well as CT\/HIV and AT groups (Mann\u2010Whitney test). Plasma of CT\/HIV and AT groups expressed similar levels of miR\u201029c\u20103p, miR\u2010155\u20105p and miR\u2010125b\u20105p. As NC group was different of CT\/HIV and AT groups, differences between three groups were statistically significant (Kruskal\u2010Wallis ANOVA test). No difference was shown between CT\/HIV and AT groups (Mann\u2010Whitney test). These results suggest the host miRNAs modulation by <jats:italic>Toxoplasma gondii<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pim.12696","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T18:38:08Z","timestamp":1579199888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Plasma extracellular microRNAs are related to AIDS\/cerebral toxoplasmosis co\u2010infection"],"prefix":"10.1111","volume":"42","author":[{"given":"Ingrid de Siqueira","family":"Pereira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular de Parasitas e Fungos Instituto Adolfo Lutz Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Marques","family":"Maia","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular de Parasitas e Fungos Instituto Adolfo Lutz Sao Paulo 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