{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:24:58Z","timestamp":1776230698573,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk018096"],"award-info":[{"award-number":["JP19fk018096"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intestinal helminthes induce immunosuppressive responses as well as type 2 immunity. Their suppressive properties are intended to regulate inflammatory diseases such as allergies and autoimmune diseases. This study evaluated whether helminthic infections suppress obesity, a chronic inflammatory state, using an intestinal nematode, <jats:italic>Heligmosomoides polygyrus<\/jats:italic> (Hp). Infection with Hp at the same time as feeding a high\u2010fat diet (HFD) prevented weight gain, dyslipidaemia and glucose intolerance observed in uninfected obese mice. Immunologically, Hp infection skewed M1 macrophages to M2 macrophages and induced type 2 innate lymphoid cells in adipose tissues. The expression of interleukin (IL)\u201033, a potent initiator of type 2 responses, was also increased in association with uncoupled protein 1 (UCP1). To further investigate the anti\u2010obesity effects of IL\u201033 in mice infected with Hp, IL\u201033\u2010deficient mice were fed the HFD and infected with Hp. These mutant mice rapidly gained weight compared with wild\u2010type mice, indicating the anti\u2010obesity effect of IL\u201033. In the absence of IL\u201033, the rapid increase in weight was not prevented, and type 2 responses and UCP1 expression were not observed even during Hp infection. These results suggested that the suppression of obesity by Hp is dependent on IL\u201033.<\/jats:p>","DOI":"10.1111\/pim.12700","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T21:10:20Z","timestamp":1581023420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["IL\u201033 is essential to prevent high\u2010fat diet\u2013induced obesity in mice infected with an intestinal helminth"],"prefix":"10.1111","volume":"42","author":[{"given":"Seiji","family":"Obi","sequence":"first","affiliation":[{"name":"Department of Parasitology Graduate School of Medicine Gunma University Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-5344","authenticated-orcid":false,"given":"Chikako","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Parasitology National Institute of Infectious Diseases Tokyo 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