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In this work, we evaluated the role of NETs and the activity of MPO in the interactions of rodent neutrophils with\u00a0amoebae and in amoebic liver abscess (ALA)\u2010resistant and ALA\u2010susceptible models. We showed with in vitro assays that mice produced greater amounts of NETs and MPO than did hamsters, and the elastase activity was high in both models. However, the inhibition of NETs and MPO promoted an increase in amoeba viability in the mice. The mouse ALAs showed a more profound presence of NETs and MPO than did the hamster ALAs. We concluded that both effector mechanisms were essential for the amoebic damage and could prevent the formation of ALAs in the resistant model.<\/jats:p>","DOI":"10.1111\/pim.12714","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T21:43:29Z","timestamp":1584567809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neutrophil extracellular traps and MPO in models of susceptibility and resistance against <i>Entamoeba histolytica<\/i>"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5273-3167","authenticated-orcid":false,"given":"Arturo","family":"Contis Montes de Oca","sequence":"first","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e investigaci\u00f3n Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional CDMX M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cruz Baquero","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e investigaci\u00f3n Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional CDMX M\u00e9xico"},{"name":"Bacteriolog\u00eda Facultad de Ciencias de la Salud Universidad Colegio Mayor de Cundinamarca Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Campos Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e investigaci\u00f3n Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional CDMX M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz Mar\u00eda","family":"C\u00e1rdenas Jaramillo","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Ciencias Morfol\u00f3gicas Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional CDMX M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eduardo","family":"Aguayo Flores","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e investigaci\u00f3n Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional CDMX M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-2664","authenticated-orcid":false,"given":"Sa\u00fal","family":"Rojas Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Celular y Molecular Secci\u00f3n de Estudios de Posgrado e investigaci\u00f3n Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional CDMX M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Olivos Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Experimental Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico CDMX M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-1812","authenticated-orcid":false,"given":"Judith","family":"Pacheco Yepez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e investigaci\u00f3n Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional CDMX M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12830-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2016006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MA0818-309RRR"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"81","article-title":"Cellular bases of experimental amebic liver abscess formation","volume":"117","author":"Tsutsumi V","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_8_6_1","article-title":"Inflammatory reaction in experimental hepatic amebiasis. 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