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The effect of prolonged\u00a0administration of bevacizumab with praziquantel was also assessed through parasitic load, protective index, granuloma and fibrous tissue evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A regression in the\u00a0vascular activity and microvascular density was\u00a0observed in the infected mice after receiving\u00a0bevacizumab. They had a significantly less VEGF\u2010R1, PCNA, CD\u201034 and \u03b1\u2010SMA expression in comparison to the infected untreated\u00a0mice. The least tissue egg count was reported in mice received bevacizumab for 6\u00a0weeks (Mean\u00a0=\u00a027\u00a0120). However, they had persistent liver granulomas, and massively amalgamated fibrosis. Interestingly, the least faecal egg and tissue worms counts (Mean\u00a0=\u00a0112, 13.4), and the\u00a0highest protection index (39.26) were reported in mice received bevacizumab for 3\u00a0weeks, with marked granuloma, and fibrous tissue resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bevacizumab\u00a0has a promising protective effect against the <jats:italic>Schistosoma<\/jats:italic>\u2010induced angiogenesis. As an adjuvant to praziquantel, it is important to adjust the appropriate\u00a0duration of administration that achieves the best schistosomicidal effect without impeding granuloma and fibrous tissue resolution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pim.12724","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T08:30:31Z","timestamp":1587976231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bevacizumab as a potential anti\u2010angiogenic therapy in schistosomiasis: A double\u2010edged, but adjustable weapon"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5972-5773","authenticated-orcid":false,"given":"Marwa A.","family":"Hasby Saad","sequence":"first","affiliation":[{"name":"Medical Parasitology Department Faculty of Medicine Tanta University Tanta Gharbia Governorate 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