{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:09:05Z","timestamp":1788307745187,"version":"build-2803163510"},"reference-count":140,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["YSS\u2010 YSS\/2014\/000773"],"award-info":[{"award-number":["YSS\u2010 YSS\/2014\/000773"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Visceral leishmaniasis (VL) is caused by a protozoan parasite <jats:italic>Leishmania donovani<\/jats:italic> mainly influencing the population of tropical and subtropical regions across the globe. The arsenal of drugs available is limited, and prolonged use of such drugs makes parasite to become resistant. Therefore, it is very imperative to develop a safe, cost\u2010effective and inexpensive vaccine against VL. Although in recent years, many strategies have been pursued by researchers, so far only some of the vaccine candidates reached for clinical trial and more than half of them are still in pipeline. There is now a broad consent among <jats:italic>Leishmania<\/jats:italic> researchers that the perseverance of parasite is very essential for eliciting a protective immune response and may perhaps be attained by live attenuated parasite vaccination. For making a live attenuated parasite, it is very essential to ensure that the parasite is deficient of virulence and should further study genetically modified parasites to perceive the mechanism of pathogenesis. So it is believed that in the near future, a complete understanding of the <jats:italic>Leishmania<\/jats:italic> genome will explore clear strategies to discover a novel vaccine. This review describes the need for a genetically modified live attenuated vaccine against VL, and obstacles associated with its development.<\/jats:p>","DOI":"10.1111\/pim.12732","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T10:24:57Z","timestamp":1589711097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genetically modified live attenuated vaccine: A potential strategy to combat visceral leishmaniasis"],"prefix":"10.1111","volume":"42","author":[{"given":"Satish Chandra","family":"Pandey","sequence":"first","affiliation":[{"name":"Cell and Molecular biology laboratory Department of Zoology Kumaun University Almora India"},{"name":"Department of Biotechnology Kumaun University Nainital India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awanish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology National Institute of Technology Raipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-2421","authenticated-orcid":false,"given":"Mukesh","family":"Samant","sequence":"additional","affiliation":[{"name":"Cell and Molecular biology laboratory Department of Zoology Kumaun University Almora India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization(2017).Leishmaniasis. Fact sheet No 375 Available online at:http:\/\/www.who.int\/mediacentre\/factsheets\/fs375\/en\/(accessed January 10"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.12.071"},{"key":"e_1_2_11_4_1","first-page":"649","article-title":"Breakthrough in the management of visceral leishmaniasis","volume":"51","author":"Thakur B","year":"2003","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087641"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.7.0.14556"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00213"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03610.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2020.105512"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"e12727","DOI":"10.1111\/pim.12727","article-title":"A spotlight on the diagnostic methods of a fatal disease Visceral Leishmaniasis","author":"Kumar A","year":"2020","journal-title":"Parasite Immunol"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"1","article-title":"Slow pace of antileishmanial drug development","volume":"4","author":"Kumar A","year":"2018","journal-title":"Parasitol Open"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S146521"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.75000"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/biohorizons\/hzp004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1553-y"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.03.017"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006001831"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00134"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00099"},{"key":"e_1_2_11_20_1","first-page":"377","article-title":"Effectiveness of leishmanization in the control of cutaneous leishmaniasis","volume":"76","author":"Nadim A","year":"1983","journal-title":"Bull Soc Pathol Exot Filiales"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.02.015"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00184-15"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.22.10267"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-4-150"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-1029-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.02.008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061141"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003588"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005398"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003198"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00143-12"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7120695"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02529"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002914"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.5026-5035.2002"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.5.2613"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.2095-2101.2003"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737182"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00083"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1086\/513439"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011319"},{"issue":"3","key":"e_1_2_11_42_1","first-page":"245","article-title":"Immune responses in kala\u2010azar","volume":"123","author":"Saha S","year":"2006","journal-title":"Indian J Med Res"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxn131"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.05.021"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1978"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01090-07"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535079"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.4.2.241"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00449-4"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00438-08"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.11.005"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.62887"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09552-X"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.06.002"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00220-5"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.04.002"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(96)00040-5"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.03.058"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05660-11"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03128-7"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532806X152890"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.08.006"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(01)00486-1"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.229-243.2001"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821996000200008"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00058-4"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00444-9"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.11.057"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.102"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.08.021"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000703"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.11.011"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.812-819.2005"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.014"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182011001417"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014644"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1086\/430348"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.7160"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900265"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008222"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005527"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00394-07"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00198"},{"issue":"7022","key":"e_1_2_11_84_1","first-page":"164","article-title":"Genetically modified Plasmodium parasites as a protective experimental malaria vaccine","volume":"433","author":"Mueller AK","year":"2005","journal-title":"Nat Genet"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/892817"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2053"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg980"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.12.019"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106806200"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33059"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01788"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700674"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01176"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600188200"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.307884"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.431486"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.228213"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.346502"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3154"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014152108"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.85"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.315"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80119-1"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.10.053"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b02130"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160087"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.12.002"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10706"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2016.06.004"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.06.047"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.3161"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003557"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005590"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2002.tb11065.x"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1006\/expr.2001.4595"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.1.62-68.2002"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.01.014"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600205"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08183.x"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002707"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3793"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3622-3627.2004"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00758.x"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.03.014"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07214.x"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202801"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.04.068"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0630165100"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160257897"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00689.x"},{"issue":"12","key":"e_1_2_11_131_1","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.4049\/jimmunol.161.12.6794","article-title":"Leishmania mexicana cysteine proteinase\u2010deficient mutants have attenuated virulence for mice and potentiate a Th1 response","volume":"161","author":"Alexander J","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(97)00072-8"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3190-3195.2003"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005658"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.032"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.02.004"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052434"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900276"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00432-7"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.1.406"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530604100"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.12732","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:27:31Z","timestamp":1693891651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,28]]},"references-count":140,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/pim.12732"],"URL":"https:\/\/doi.org\/10.1111\/pim.12732","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,28]]},"assertion":[{"value":"2019-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12732"}}