{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:14:04Z","timestamp":1776179644853,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["2015\u2010255173"],"award-info":[{"award-number":["2015\u2010255173"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Industrial growth has increased the exposure to endocrine disruptor compounds (EDCs) in all organisms. Bisphenol A (BPA), an EDC, has been demonstrated to be involved in the susceptibility to parasite infections. However, few studies have analysed this connection in more depth. The aim of this study was to determine whether early BPA exposure in female mice affects the systemic immune response and the susceptibility to <jats:italic>Taenia\u00a0crassiceps<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>BALB\/c mice were exposed to BPA at post\u2010natal day 3. At 6\u00a0weeks of age, they were inoculated with <jats:italic>T\u00a0crassiceps<\/jats:italic> larvae and, 2\u00a0weeks later, were euthanized. The number of parasites was quantified. By flow cytometry, in the spleen, the peripheral and mesenteric lymph nodes, the different innate and adaptive immune cell modulation was analysed, and RT\u2010PCR cytokine expression was also evaluated. BPA induced a reduction of 40% in parasite load. BPA treatment modulated some lineages of the innate immune response and caused slight changes in cells belonging to the adaptive immune response. Additionally, BPA enhanced the type 2 cytokine profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neonatal BPA treatment in female mice affects not only the percentage of different immune cells but also their ex vivo cytokine gene expression, decreasing <jats:italic>T\u00a0crassiceps<\/jats:italic> cysticercosis susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pim.12733","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T18:25:38Z","timestamp":1589739938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bisphenol A induces protection through modulation of the immune response against the helminth parasite <i>Taenia crassiceps<\/i>"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2223-6703","authenticated-orcid":false,"given":"Karen 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Ambientales Departamento de Ciencias Ambientales Centro de Ciencias de la Atm\u00f3sfera Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7868-6407","authenticated-orcid":false,"given":"Victor Hugo","family":"Del Rio\u2010Araiza","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Veterinaria y Zootecnia Departamento de Parasitolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-5948","authenticated-orcid":false,"given":"Romel","family":"Hernandez\u2010Bello","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Departamento de Microbiolog\u00eda y Parasitolog\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3 Monterrey 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