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Following the initial liver\u2010stage infection, parasites transform into merozoites, infecting red blood cells (RBCs). Repeated RBC infection then occurs during the blood\u2010stage infection, while patients experience various malarial symptoms. Protective immune responses are elicited by this systemic infection, but excessive responses are sometimes harmful for hosts. As parasites infect only RBCs and their immediate precursors during this stage, direct parasite\u2010host interactions occur primarily in the environment surrounded by endothelial lining of blood vessels. The spleen is the major organ where the immune system encounters infected RBCs, causing immunological responses. Its tissue structure is markedly altered during malarial infection in mice and humans.\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    parasites inside RBCs express proteins, such as PfEMP\u20101 and RIFIN, transported to the RBC surfaces in order to evade immunological attack by sequestering themselves in the peripheral vasculature avoiding spleen or by direct immune cell inhibition through inhibitory receptors. Host cell production of regulatory cytokines IL\u201010 and IL\u201027 limits excessive immune responses, avoiding tissue damage. The regulation of the protective and inhibitory immune responses through host\u2010parasite interactions allows chronic\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection. In this review, we discuss underlying interaction mechanisms relevant for developing effective strategies against malaria.\n                  <\/jats:p>","DOI":"10.1111\/pim.12763","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T12:51:50Z","timestamp":1591275110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Host\u2010pathogen interaction in the tissue environment during\n                    <i>Plasmodium<\/i>\n                    blood\u2010stage infection"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-2496","authenticated-orcid":false,"given":"Katsuyuki","family":"Yui","sequence":"first","affiliation":[{"name":"Division of Immunology Department of Molecular Microbiology and Immunology Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"},{"name":"School of Tropical Medicine and Global Health Nagasaki 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