{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:45Z","timestamp":1772160885527,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["# 302174\/2017\u20106"],"award-info":[{"award-number":["# 302174\/2017\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Skin lesions in nonulcerated cutaneous leishmaniasis (NUCL) caused by\n                    <jats:italic>Leishmania (L.) infantum chagasi<\/jats:italic>\n                    are characterized by a mononuclear inflammatory infiltrate in the dermis, which is composed mainly of lymphocytes, followed by macrophages, few plasma cells and epithelioid granulomas with mild tissue parasitism. Previous studies have shown that the main population of lymphocytes present in the dermal infiltrate is CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, followed by CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, which are correlated with IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    cells. To improve the knowledge of cellular immune responses in NUCL, skin biopsies were submitted to immunohistochemistry using anti\u2010ROR\u2010\u03b3t, anti\u2010IL\u201017, anti\u2010IL\u20106, anti\u2010TGF\u2010\u03b2, and anti\u2010IL\u201023 antibodies to characterize the involvement of Th17 cells in the skin lesions of patients affected by NUCL. ROR\u2010\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    , IL\u201017\n                    <jats:sup>+<\/jats:sup>\n                    , IL\u20106\n                    <jats:sup>+<\/jats:sup>\n                    , TGF\u2010\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    and IL\u201023\n                    <jats:sup>+<\/jats:sup>\n                    cells were observed in the dermal inflammatory infiltrate of NUCL skin lesions. A positive correlation between CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocytes and ROR\u2010\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    and IL\u201017\n                    <jats:sup>+<\/jats:sup>\n                    cells suggests that some of the CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocytes in NUCL could be Th17 lymphocytes. Moreover, a positive correlation between ROR\u2010\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    cells and TGF\u2010\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    , IL\u20106\n                    <jats:sup>+<\/jats:sup>\n                    , IL\u201017\n                    <jats:sup>+<\/jats:sup>\n                    and IL\u201023\n                    <jats:sup>+<\/jats:sup>\n                    cells could indicate the role of these cytokines in the differentiation and maintenance of Th17 lymphocytes. Our findings improve knowledge of the pathogenesis of this rare and atypical clinical form of leishmaniasis.\n                  <\/jats:p>","DOI":"10.1111\/pim.12772","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T17:42:57Z","timestamp":1593538977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Th17 lymphocytes in atypical cutaneous leishmaniasis caused by\n                    <i>Leishmania (L.) infantum chagasi<\/i>\n                    in Central America"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-7298","authenticated-orcid":false,"given":"Gabriela Venicia","family":"Araujo Flores","sequence":"first","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-4869","authenticated-orcid":false,"given":"Carmen Maria","family":"Sandoval Pacheco","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfredo Humberto","family":"Sosa Ochoa","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"},{"name":"Microbiology Research Institute National Autonomous University of Honduras Tegucigalpa Honduras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Maria Castro","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Z\u00faniga","sequence":"additional","affiliation":[{"name":"Health Surveillance Department University School Hospital Tegucigalpa Honduras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos P.","family":"Corbett","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-2440","authenticated-orcid":false,"given":"Marcia Dalastra","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90734-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12295"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02426.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00301"},{"key":"e_1_2_8_6_1","first-page":"51","article-title":"Immunology of leishmaniasis","volume":"14","author":"Mutiso JM","year":"2013","journal-title":"Sci Parasitol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3487591"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1539"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-45082013000200019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2016.07.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2009.42.12.776"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2007.tb04008.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1551"},{"key":"e_1_2_8_15_1","volume-title":"Manual de manejo de enfermedades parasitarias prioritarias en Honduras, Segunda","author":"OPS","year":"2009"},{"issue":"02","key":"e_1_2_8_16_1","first-page":"e1000206","article-title":"Pro\u2010 and anti\u2010inflammatory cytokines in visceral leishmaniasis","volume":"6","author":"Andargie TE","year":"2015","journal-title":"J Cell Sci Ther"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070663"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407679-2.00005-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2608"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00626.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2348"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07036"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00628.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/599380"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700674"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01437"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003243"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.5.12862"},{"key":"e_1_2_8_32_1","first-page":"2379","article-title":"IL\u201017 and IL\u201022 are associated with protection against human kala azar caused by Leishmania donovani","volume":"119","author":"Pitta MGR","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040384"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis771"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0713598"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903332"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.128"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker316"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00949"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3786"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2016.1232042"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1443.021"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940115"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12420"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-14-52"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu531"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00154-09"},{"key":"e_1_2_8_48_1","first-page":"30","article-title":"Prophylactic interferon\u2010\u03b3 and interleukin\u201017 facilitate parasite clearance in experimental visceral leishmaniasis","volume":"9","author":"Kumar P","year":"2019","journal-title":"Trop Parasitol"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpim.12772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.12772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:28:03Z","timestamp":1693326483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/pim.12772"],"URL":"https:\/\/doi.org\/10.1111\/pim.12772","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.12772\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12772\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12772\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12772\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12772\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12772\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"2020-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12772"}}