{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:42:13Z","timestamp":1784011333576,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ICMR\u2010GAP370"],"award-info":[{"award-number":["ICMR\u2010GAP370"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Leishmania donovani<\/jats:italic>\n                      , the causative agent for visceral leishmaniasis (VL), modulates host monocytes\/macrophages to ensure its survival. However, knowledge regarding the host\u2010parasite interactions underpinning the disease remains limited. As disease progression is associated with polarization of monocytes\/macrophages towards M2, which is regulated by cytokines IL\u20104\/IL\u201013 and IL\u201010, this study evaluated the status of key IL\u20104\u2010 and IL\u201010 driven markers in experimental models of VL, as also evaluated their correlation, if any, with parasite load.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In liver and splenic tissues from\n                      <jats:italic>L donovani<\/jats:italic>\n                      <jats:bold>\u2013<\/jats:bold>\n                      infected hamsters and BALB\/c mice, the parasite burden was determined along with mRNA expression of IL\u20104\n                      <jats:bold>\u2013<\/jats:bold>\n                      driven markers, that is\n                      <jats:italic>CD206, Arginase\u2010I, CCL17, CCL22, PPAR\u2010\u03b3, STAT6, KLF4, FIZZ1<\/jats:italic>\n                      and\n                      <jats:italic>YM1<\/jats:italic>\n                      along with IL\u201010\n                      <jats:bold>\u2013<\/jats:bold>\n                      driven markers,\n                      <jats:italic>CXCL13, IL\u201010, TGF\u2010\u03b2, VDR, CCR2<\/jats:italic>\n                      and\n                      <jats:italic>CYP27A1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mRNA expression of IL\u20104\u2010 and IL\u201010\n                      <jats:bold>\u2013<\/jats:bold>\n                      driven markers was enhanced in both models, but only in the hamster model, the splenic tissues demonstrated a positive correlation between all the IL\u201010\n                      <jats:bold>\u2013<\/jats:bold>\n                      driven markers and parasite load.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Contrary to human VL, both models demonstrated an increased expression of IL\u20104\u2010 and IL\u201010\n                      <jats:bold>\u2013<\/jats:bold>\n                      driven markers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12783","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T03:08:42Z","timestamp":1596164922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Status of IL\u20104 and IL\u201010 driven markers in experimental models of Visceral Leishmaniasis"],"prefix":"10.1111","volume":"43","author":[{"given":"Srija","family":"Moulik","sequence":"first","affiliation":[{"name":"Department of Pharmacology Institute of Postgraduate Medical Education and Research Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyshree","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research (CSIR)\u2010Indian Institute of Chemical Biology Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Parasitology CSIR\u2010Central Drug Research Institute Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Dube","sequence":"additional","affiliation":[{"name":"Division of Parasitology CSIR\u2010Central Drug Research Institute Lucknow 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