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Therefore, there is an urgent need for new antileishmanial agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      In this study, the antileishmanial activity of a diprenylated flavonoid called 5,7,3,4\u2019\u2010tetrahydroxy\u20106,8\u2010diprenylisoflavone (CMt) was tested against\n                      <jats:italic>Leishmania infantum<\/jats:italic>\n                      and\n                      <jats:italic>L amazonensis<\/jats:italic>\n                      species. Results showed that CMt presented selectivity index (SI) of 70.0 and 165.0 against\n                      <jats:italic>L infantum<\/jats:italic>\n                      and\n                      <jats:italic>L amazonensis<\/jats:italic>\n                      promastigotes, respectively, and of 181.9 and 397.8 against respective axenic amastigotes. Amphotericin B (AmpB) showed lower SI values of 9.1 and 11.1 against\n                      <jats:italic>L infantum<\/jats:italic>\n                      and\n                      <jats:italic>L amazonensis<\/jats:italic>\n                      promastigotes, respectively, and of 12.5 and 14.3 against amastigotes, respectively. CMt was effective in the treatment of infected macrophages and caused alterations in the parasite mitochondria.\n                      <jats:italic>L infantum<\/jats:italic>\n                      \u2010infected mice treated with miltefosine, CMt alone or incorporated in polymeric micelles (CMt\/Mic) presented significant reductions in the parasite load in distinct organs, when compared to the control groups. An antileishmanial Th1\u2010type cellular and humoral immune response were developed one and 15\u00a0days after treatment, with CMt\/Mic\u2010treated mice presenting a better protective response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that CMt\/Mic could be evaluated as a chemotherapeutic agent against VL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12784","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T15:35:43Z","timestamp":1596987343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis"],"prefix":"10.1111","volume":"42","author":[{"given":"Isabela A. 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