{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:04:02Z","timestamp":1782248642831,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2046"],"award-info":[{"award-number":["GRK2046"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n IgA and Th17 responses are pivotal for the control of\n Giardia<\/jats:italic>\n infections. Eosinophils support IgA class switching, the survival of intestinal IgA\n +<\/jats:sup>\n plasma cells at steady state and can control Th17 activity in the small intestine. To see whether eosinophils regulate adaptive immune responses during giardiasis, we investigated\n Giardia muris<\/jats:italic>\n infections in wild\u2010type BALB\/c and eosinophil\u2010deficient \u2206dblGATA\u20101 mice.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n Infected \u2206dblGATA\u20101 mice did not differ markedly in parasite control from wild\u2010type mice. Confirming previous studies, naive \u2206dblGATA\u20101 mice displayed diminished IgA\n +<\/jats:sup>\n B cell frequencies in Peyer's patches. However, IgA class switching and intestinal IgA secretion in response to\n G muris<\/jats:italic>\n infection were comparable in wild\u2010type BALB\/c and \u2206dblGATA\u20101 mice. Both strains displayed similarly low intestinal Th17 responses, accompanied by a mild expansion of type 3 innate lymphoid cells (ILC3).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Contrasting previous reports on overt small intestinal Th17 activity in eosinophil\u2010deficient mice, IL\u201017A production is kept in check in the absence of eosinophils during\n Giardia<\/jats:italic>\n infection. Suboptimal homeostatic IgA responses in the absence of eosinophils are transiently fostered in infected mice and the maintenance of IgA\n +<\/jats:sup>\n plasma cells appears to be restored during persisting\n Giardia<\/jats:italic>\n infection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pim.12791","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T03:55:41Z","timestamp":1600919741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Eosinophils are dispensable for the regulation of IgA and Th17 responses in\n Giardia muris<\/i>\n infection"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4119-7308","authenticated-orcid":false,"given":"Ivet A.","family":"Yordanova","sequence":"first","affiliation":[{"name":"Center for Infection Medicine Institute of Immunology Freie Universit\u00e4t Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lamatsch","sequence":"additional","affiliation":[{"name":"Department of Biology, Chemistry and Pharmacy Institute of Pharmacy Freie Universit\u00e4t Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja A.","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Core Unit for Immunopathology for Experimental Models iPATH.Berlin Charit\u00e9 \u2010 University Medicine Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Center for Infection Medicine Institute of Immunology Freie Universit\u00e4t Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rausch","sequence":"additional","affiliation":[{"name":"Center for Infection Medicine Institute of Immunology Freie Universit\u00e4t Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001920"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00648-15"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.1.11-18.2002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.6281"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2015.06.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01536-14"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08590-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56416-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2016018726"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0281-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.0034"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12728"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.123"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1981"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141388"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172049"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.93"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00343-16"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025062"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02958.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2009.106"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-016-0153-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80097-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90100-5"},{"key":"e_1_2_9_27_1","first-page":"1","article-title":"Eosinophil\u2010associated innate IL\u201017 response promotes Aspergillus fumigatus lung pathology","volume":"9","author":"Malacco NLS","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006175"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.12791","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T02:11:37Z","timestamp":1693620697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/pim.12791"],"URL":"https:\/\/doi.org\/10.1111\/pim.12791","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.12791\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12791\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12791\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12791\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12791\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,23]]},"assertion":[{"value":"2020-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12791"}}