{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:48Z","timestamp":1772160888947,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","award":["BY2017KYQD12"],"award-info":[{"award-number":["BY2017KYQD12"]}],"id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012905","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016HM19"],"award-info":[{"award-number":["ZR2016HM19"]}],"id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010669","name":"Department of Health of Shandong Province","doi-asserted-by":"publisher","award":["2017WS884"],"award-info":[{"award-number":["2017WS884"]}],"id":[{"id":"10.13039\/501100010669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011482","name":"Yantai Science and Technology Bureau","doi-asserted-by":"publisher","award":["2015ZH084"],"award-info":[{"award-number":["2015ZH084"]}],"id":[{"id":"10.13039\/501100011482","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells\u2019 distribution and population change in BALB\/c and FVB mice infected by\n                      <jats:italic>C sinensis<\/jats:italic>\n                      and their function in liver damage were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Mice were infected by\n                      <jats:italic>Clonorchis sinensis<\/jats:italic>\n                      metacercariae, and lymphocytes were isolated from the livers, spleens and peripheral blood. NK, DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT, INF\u2010\u03b3\n                      <jats:sup>+<\/jats:sup>\n                      DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells and liver fibrosis were analysed. The DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells displayed the largest amount in normal BALB\/c mice liver followed by peripheral blood and spleen. Although the hepatic DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells of BALB\/c mice were more than that of FVB mice, they did not show significant percentage change after\n                      <jats:italic>C sinensis<\/jats:italic>\n                      infection. The hepatic DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells of FVB mice increased remarkably after infection accompanied with heavier liver injury and fibrosis than the BALB\/c mice. And hydroxyproline content was also positively correlated with DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells only in FVB mice. However, the increase of IFN\u2010\u03b3 producing DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells was lower in FVB mice than in BALB\/c mice which showed sharp increase with mild liver damage after infection. The frequencies of anti\u2010fibrotic NK cells were similar in both of the two mouse strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>C sinensis<\/jats:italic>\n                      could induce different DX5\n                      <jats:sup>+<\/jats:sup>\n                      NKT cells responses in different mouse strains which may play roles in liver injury and fibrosis in FVB mice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12796","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T23:56:27Z","timestamp":1601250987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["DX5\n                    <sup>+<\/sup>\n                    NKT cells\u2019 increase was correlated with liver damage in FVB mice not in BALB\/c mice infected by\n                    <i>Clonorchis sinensis<\/i>"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1319-8442","authenticated-orcid":false,"given":"Xuelian","family":"Bai","sequence":"first","affiliation":[{"name":"Clinical Medicine Laboratory Binzhou Medical University Hospital Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Medicine Laboratory Binzhou Medical University Hospital Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Medicine Laboratory Binzhou Medical University Hospital Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Binzhou City People's Hospital Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuening","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Immunology Shandong College of Traditional Chinese Medicine Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Medicine Laboratory Binzhou Medical University Hospital Binzhou 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