{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:27:11Z","timestamp":1789900031240,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early biomarkers of the response to treatment are lacking and may help to reduce mortality by the vector\u2010borne disease visceral leishmaniasis (VL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted to investigate plasma cytokines and clinical laboratory data as biomarkers of the early response to specific treatment for VL in 36 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean interleukin 6 (IL\u20106) concentration on the 7th day was 2.3% of the pre\u2010treatment concentration, interleukin 10 (IL\u201010) was 8.0%, and interleukin 8 (IL\u20108) was 8.2%. On the 7th day, IL\u201010 was below half of the pre\u2010treatment concentration in 100.0%, IL\u20108 in 95.5% and IL\u20106 in 90.9%. The spleen and liver sizes, haemoglobin, interleukin 1 beta (IL\u20101\u03b2) and tumour necrosis factor alpha (TNF\u2010\u03b1) showed a slower recovery. Fever disappeared in 91% on the 7th day, 69.4% had a normal white cell count, and 77.8% had a normal platelet value by this time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The plasma cytokines IL\u20106, IL\u201010 and IL\u20108 were demonstrated to be excellent markers of the early response to VL treatment and if tested before the 7th day, will likely prove to be better than fever measurement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12797","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T23:45:26Z","timestamp":1601250326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biomarkers of the early response to treatment of visceral leishmaniasis: A prospective cohort study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3013-8778","authenticated-orcid":false,"given":"Simone","family":"S. Lima","sequence":"first","affiliation":[{"name":"Maternal and Childhood Department Federal University of Piau\u00ed Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Cavalcante Braz","sequence":"additional","affiliation":[{"name":"Pharmacy Course Federal University of Piau\u00ed Teresina Brazil"},{"name":"Laboratory of Leishmaniasis Natan Portella Institute of Tropical Medicine Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Costa Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Leishmaniasis Natan Portella Institute of Tropical Medicine Teresina Brazil"},{"name":"Intelligence Center for Emerging and Neglected Tropical Diseases (CIATEN) Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresinha","family":"J. C. 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