{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:46Z","timestamp":1772160886502,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Following treatment, cystic echinococcosis (CE) exhibits a relatively high relapse rate. Here, we evaluated the value of soluble programmed death\u20101 (sPD\u20101), sPD\u20101 ligand (sPD\u2010L1) and anti\u2010recP29 antibody concentrations, as predictors of early surgical treatment outcomes in young CE\u2010affected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      This prospective study included 59 Tunisian children (177 plasmas), where CE was surgically treated and monitored for 3 post\u2010operative years. Based on CE post\u2010surgical development, patients were clustered into a \u2018No relapsed\u2019 CE (NRCE; n\u00a0=\u00a039) and a \u2018Relapsed\u2019 CE (RCE; n\u00a0=\u00a020) group. Plasma levels of sPD\u20101, sPD\u2010L1 and anti\u2010recP29 IgG were measured using ELISA. In the NRCE group, sPD\u20101, sPD\u2010L1 and anti\u2010recP29 IgG concentrations were significantly lower at D365 than at D30. By contrast, in the RCE group, no significant difference was observed between D0, D30 and D365. When considering individual variations, the probability to be \u2018relapse\u2010free\u2019 was 67% and 73% when anti\u2010recP29 IgG and sPD\u2010L1 level, respectively, decreased between D30 and D365. The probability to be \u2018relapse\u2010free\u2019 was 86% when the sPD\u20101 level decreased between D30 and D365 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003; chi\u2010square test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sPD\u20101 may be a useful biomaker for the early evaluation of surgical procedure efficacy in paediatric CE cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12809","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T18:46:04Z","timestamp":1605725164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Soluble programmed death\u20101 (sPD\u20101) as predictor of early surgical outcomes of paediatric cystic echinococcosis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-880X","authenticated-orcid":false,"given":"Eya","family":"Ben Salah","sequence":"first","affiliation":[{"name":"Departement de Biologie clinique B Facult\u00e9 de Pharmacie Laboratoire de Parasitologie\u2010Mycologie M\u00e9dicale et Mol\u00e9culaire LR12ES08 Universit\u00e9 de Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-8598","authenticated-orcid":false,"given":"Wahiba","family":"Sakly","sequence":"additional","affiliation":[{"name":"Departement de Biologie clinique B Facult\u00e9 de Pharmacie Laboratoire de Parasitologie\u2010Mycologie M\u00e9dicale et Mol\u00e9culaire LR12ES08 Universit\u00e9 de Monastir  Monastir 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