{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:13:57Z","timestamp":1792196037650,"version":"4.4.0"},"reference-count":176,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI131656"],"award-info":[{"award-number":["R01AI131656"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI146841"],"award-info":[{"award-number":["R21AI146841"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The bacterial pathogen\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    is the causative agent of Lyme disease and is transmitted to humans through an\n                    <jats:italic>Ixodes<\/jats:italic>\n                    tick vector.\n                    <jats:italic>B.\u00a0burgdorferi<\/jats:italic>\n                    is able to survive in both mammalian and tick hosts through careful modulation of its gene expression. This allows\n                    <jats:italic>B.\u00a0burgdorferi<\/jats:italic>\n                    to adapt to the environmental and nutritional changes that occur when it is transmitted between the two hosts. Distinct interactions between the spirochete and its host occur at every step of the enzootic cycle and dictate the ability of the spirochete to survive until the next stage of the cycle. Studying the interface between\n                    <jats:italic>B.\u00a0burgdorferi<\/jats:italic>\n                    , the\n                    <jats:italic>Ixodes<\/jats:italic>\n                    tick vector and the natural mammalian reservoirs has been made significantly more feasible through the complete genome sequences of the organisms and the advent of high throughput screening technologies. Ultimately, a thorough investigation of the interplay between the two domains (and two phyla within one domain) is necessary in order to completely understand how the pathogen is transmitted.\n                  <\/jats:p>","DOI":"10.1111\/pim.12816","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T05:56:56Z","timestamp":1608962216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Interactions between\n                    <i>Borrelia burgdorferi<\/i>\n                    and its hosts across the enzootic cycle"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3518-069X","authenticated-orcid":false,"given":"Jennifer D.","family":"Helble","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Microbiology Tufts University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6370-5951","authenticated-orcid":false,"given":"Julie E.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Microbiology Tufts University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-5558","authenticated-orcid":false,"given":"Linden T.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Microbiology Tufts University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2714"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2741\/3200"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.02.010"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12609"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.1689-1705.2003"},{"issue":"3","key":"e_1_2_12_7_1","first-page":"205","article-title":"Gene regulation during the enzootic cycle of the lyme disease spirochete","volume":"7","author":"Samuels DS","year":"2016","journal-title":"For Immunopathol Dis Therap"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0400-5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.09.003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2013.1758"},{"issue":"2","key":"e_1_2_12_11_1","first-page":"141","article-title":"Reaction of the host to the tick bite III. The bite of viruliferous Ixodes ricinus female","volume":"242","author":"Nosek J","year":"1978","journal-title":"Zentralbl Bakteriol Orig A"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-024937-7.50009-3"},{"key":"e_1_2_12_13_1","first-page":"1","article-title":"Tick salivary compounds: their role in modulation of host defences and pathogen transmission","volume":"4","author":"Kazim\u00edrov\u00e1 M","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00337"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2741\/3363"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1990.42.352"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07687.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05136-11"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2015.08.013"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002133"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00050-13"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MR.57.2.320-346.1993"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06621.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05153-11"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00075-11"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.11.2568"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1237"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00116"},{"issue":"14401","key":"e_1_2_12_29_1","first-page":"1","article-title":"Infection\u2010derived lipids elicit an immune deficiency circuit in arthropods","volume":"8","author":"Shaw DK","year":"2017","journal-title":"Nat Commun"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.54.110807.090559"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078376"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931028"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215696"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)01918-3"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1991.0097"},{"key":"e_1_2_12_36_1","first-page":"1","article-title":"A novel tick protein supports integrity of gut peritrophic matrix impacting existence of gut microbiome and Lyme disease pathogens","author":"Yang X","year":"2020","journal-title":"Cell Microbiol"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.06.001"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13965"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-018-0161-6"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9040309"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00142"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-016-0103-7"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0267-5"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00211"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.12.001"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613422114"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00208-0"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030033"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031960"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7398"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9427"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.1.382-388.2000"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.670"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.6.3536-3541.2001"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390401"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2237407"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390402"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.271"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.8.3146-3150.1997"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1755-1759.2004"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.5.1908-1915.1997"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.10.027"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00426-20"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.179.16.5188-5194.1997"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.179.23.7251-7256.1997"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05550.x"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12068"},{"issue":"4","key":"e_1_2_12_68_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JB.00582-18","article-title":"DksA controls the response of the lyme disease spirochete borrelia burgdorferi to starvation","volume":"201","author":"Boyle WK","year":"2019","journal-title":"J Bacteriol"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14504"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502565102"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00315-15"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002102"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13437"},{"issue":"3","key":"e_1_2_12_74_1","doi-asserted-by":"crossref","first-page":"MBP\u20100011\u20102014","DOI":"10.1128\/microbiolspec.MBP-0011-2014","article-title":"Borrelia burgdorferi: Carbon metabolism and the tick\u2010mammal enzootic cycle","volume":"3","author":"Corona A","year":"2015","journal-title":"Microbiol Spectr"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1089\/1530366041210738"},{"issue":"108","key":"e_1_2_12_76_1","first-page":"1","article-title":"Chitobiose utilization in Borrelia burgdorferi is dually regulated by RpoD and RpoS","volume":"9","author":"Rhodes RG","year":"2009","journal-title":"BMC Microbiol"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2012.00996.x"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005160"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118063"},{"issue":"4","key":"e_1_2_12_80_1","first-page":"585","article-title":"Comparative genomics and evolution of genes encoding bacterial (p)ppGpp synthetases\/hydrolases (the Rel, RelA and SpoT proteins)","volume":"3","author":"Mittenhuber G","year":"2001","journal-title":"J Mol Microbiol Biotechnol"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.3.957-965.2003"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.4972-4981.2005"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.397"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.7.3181-3187.1999"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2739-2742.2001"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02104.x"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5419-5432.2004"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.11.4145-4148.2001"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39401"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44394"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00514-12"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00450-09"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00199-07"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2007.12.013"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01760-06"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02047-17"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.22.6198-6206.2002"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.1.51-60.2004"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/17.5.403"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00917-15"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2004.12.002"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.20.1.215-220.1978"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038171"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003109"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07691.x"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01397"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006225"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047532"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007644"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05860.x"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01802-08"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834315100"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01721-08"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00467-08"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/019992-0"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231442498"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01923"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.11.6433-6445.2004"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408536102"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-44"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01228-12"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12617"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1086\/651172"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00521-12"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00372-10"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00140-13"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1365-0"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004278"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002079"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006410"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004323"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2005.11.005"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.205.18.2843"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2015.03.012"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.039289"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09103"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2018.12.001"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00325-4"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040031"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01975.x"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6579"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.7.4319"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111391200"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03034-3"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6186"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1497"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03812"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.10.006"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2003.00605.x"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00232-08"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.06.010"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001486200"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2007.00742.x"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.10.020"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.5.2989-2994.2004"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01507-08"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.36.92"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056365"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01964030"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.1.335-338.1997"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000451"},{"issue":"1","key":"e_1_2_12_163_1","first-page":"36","article-title":"Hypersensitivity to ticks and Lyme disease risk","volume":"11","author":"Burke G","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001205"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2005.00575.x"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513010200"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703143200"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.07.053"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5209"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015926"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405763102"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.10.044"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.07.100"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.089"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05226-11"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10507"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw6441"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.12816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T18:50:18Z","timestamp":1693594218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":176,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/pim.12816"],"URL":"https:\/\/doi.org\/10.1111\/pim.12816","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.12816\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12816\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12816\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12816\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12816\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"2020-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12816"}}