{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:32:54Z","timestamp":1792423974731,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    It is known that miRNAs are effective in immune response in the diagnosis and treatment of many infectious diseases. However, the miRNAs profile is unknown in Alveolar and Cystic Echinococcosis which can be fatal if left untreated. The miRNAs profile that activates the T and B cells forming the immune system in Alveolar and Cystic Echinococcosis patients was investigated in this study. A total of 50 liver tissue samples were obtained from Alveolar and Cystic Echinococcosis patients in Kilis State Hospital Pathology Laboratory in southeast of Turkey. The circulating cell\u2010free miRNAs were evaluated by a quantitative real\u2010time polymerase chain reaction, statistically calculated within \u0394\u0394Ct values and fold changes were evaluated by Welch\n                    <jats:italic>T<\/jats:italic>\n                    test, in which\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a0.05 was considered to be significant. Twenty\u2010five microRNAs, including let\u20107a\u20105p, let\u20107c, let\u20107e\u20105p, miR\u201015b\u20105p, miR16, miR\u201017\u20105p, miR\u201023a\u20105p, miR\u201024\u20103p, miR\u201025\u20103p, miR\u201026a\u20103p, miR\u201026b\u20103p, miR\u201029b\u20103p, miR\u201029c\u20103p, miR\u201030a\u20105p, miR\u201030b\u20105p, miR\u201030c\u20105p, miR\u201030d\u20105p, miR\u201030e\u20105p, miR\u201098\u20105p, miR\u2010101\u20103p, miR\u2010106b\u20105p, miR\u2010125b\u20105p, miR\u2010142\u20105p, miR\u2010222\u20103p and miR\u2010223\u20103p, were found as down\u2010regulated in Alveolar and Cystic Echinococcosis patients than control groups. Twelve miRNAs, including miR\u201015a\u20105p, miR\u201021\u20105p, miR\u201027a\u20103p, miR\u201029a\u20103p, miR\u2010146a\u20105p, miR\u2010181a\u20105p, miR\u2010181b\u20105p, miR\u2010181d, miR\u2010181c\u20105p, miR\u2010195\u20105p, miR\u2010214\u20103p and miR\u2010365\u20103p, were found as up\u2010regulated in Alveolar and Cystic Echinococcosis patients than healthy person. It has been shown that T\u2010 and B\u2010cell activities are related in the progressive of both Alveolar and Cystic Echinococcosis in this study. The miRNA panel activated by T and B cells may be important for exploring the mechanisms underlying early development in Alveolar and Cystic Echinococcosis providing novel information that may be used to discover new therapeutics for these diseases.\n                  <\/jats:p>","DOI":"10.1111\/pim.12817","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T08:33:25Z","timestamp":1610267605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["MicroRNA profile in immune response of alveolar and cystic echinococcosis patients"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-1326","authenticated-orcid":false,"given":"Fadime","family":"Eroglu","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Parasitology Aksaray University Aksaray Turkey"},{"name":"FaBiyosit Microbiology\u2010Biotechnology R&amp;D Co. Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Dokur","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Emergency Medicine Biruni University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00fcksel","family":"Ulu","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology Kilis State Hospital Kilis Turkey"},{"name":"Department of Medical Pathology Istanbul Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007932"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2016.11.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2020024"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"e0008242","DOI":"10.1371\/journal.pntd.0008242","article-title":"Genetic diversity of Echinococcus multilocularis and Echinococcus granulosus sensu lato in Krygzstan: the A2 haplotype of E.multilocularis is the predominant variant infecting humans","volume":"14","author":"Alvares Rojas CA","year":"2020","journal-title":"Plos Negl Trop Dis"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-736"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12395"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst155"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029979"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5578\/mb.21005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.06.040"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2009.07.010"},{"key":"e_1_2_9_15_1","unstructured":"AnayaJM ShoenfeldY Rojas\u2010VillarragaA et al.Autoimmunity: From Bench to Beside Chapter 5 Introduction to T and B lymphocytes R Luz Elena Cano and H. Damaris E. Lopera 2013 Jul 18. El Rosario University Press."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191812"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02148"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.5.1688-1697.1995"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.01.016"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.11.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2014.03.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002701"},{"key":"e_1_2_9_23_1","article-title":"miRNAs and IncRNAs in Echinococcus in Echinococcosis","volume":"22","author":"He Z","year":"2020","journal-title":"Int J Mol Sci"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.09.004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017000300"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2013.08.008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2019.102039"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.3.1168-1174.2002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017156"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.12817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T14:16:21Z","timestamp":1693404981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/pim.12817"],"URL":"https:\/\/doi.org\/10.1111\/pim.12817","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.12817\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12817\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,7]]},"assertion":[{"value":"2020-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12817"}}