{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:49:13Z","timestamp":1788414553770,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 0973"],"award-info":[{"award-number":["PIP 0973"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007351","name":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 20020130100652BA"],"award-info":[{"award-number":["UBACyT 20020130100652BA"]}],"id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The goal of this study was to analyse the effects of a protein\u2010deficient (PD) diet on antibody\u2010dependent cell\u2010mediated cytotoxicity (ADCC) in vitro against newborn larvae (NBL) of <jats:italic>Trichinella spiralis<\/jats:italic> in the lungs of infected rats. Two groups of weaning Wistar rats received a PD diet (6.5% casein) and other two received a control diet (C, 20% casein). After ten days, one group of each diet was infected (PD<jats:sub>I<\/jats:sub> and C<jats:sub>I<\/jats:sub>) with muscle larvae. Lung tissue extracts (LTE) and lung cell suspension (LCS) were obtained. PD<jats:sub>I<\/jats:sub> had lower titres of anti\u2010NBL antibodies in LTE than C<jats:sub>I<\/jats:sub>. In ADCC assays using control cells, NBL mortality percentage was lower with LTE from PD<jats:sub>I<\/jats:sub> than LTE from C<jats:sub>I<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). In assays using control cytotoxic sera, ADCC was exerted by LCS from C<jats:sub>I<\/jats:sub> at all days post\u2010infection (p.i.), but only by LCS from 13\u00a0days p.i. from PD<jats:sub>I<\/jats:sub>. ADCC assays combining LTE and LCS from the same group showed a lower response for PD<jats:sub>I<\/jats:sub> than for C<jats:sub>I<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). LCS from PD<jats:sub>I<\/jats:sub> contained lower numbers of neutrophils, eosinophils and Fc\u03b5RI<jats:sup>+<\/jats:sup> cells than C<jats:sub>I<\/jats:sub>. PD may diminish ADCC activity against <jats:italic>T spiralis<\/jats:italic> NBL in lungs through alterations in specific antibodies and effector cells.<\/jats:p>","DOI":"10.1111\/pim.12820","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T09:56:46Z","timestamp":1610704606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Protein deficiency during <i>Trichinella spiralis<\/i> infection impairs lung immunity against newborn larvae"],"prefix":"10.1111","volume":"43","author":[{"given":"Cecilia C.","family":"Vila","sequence":"first","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU) CONICET\u2010Universidad de Buenos Aires Buenos Aires 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H.","family":"Falduto","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU) CONICET\u2010Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00e1ngeles","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU) CONICET\u2010Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela A.","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU) CONICET\u2010Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabel N.","family":"Pallaro","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Nutrici\u00f3n Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2500-6682","authenticated-orcid":false,"given":"Pablo C.","family":"Baldi","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral (IDEHU) CONICET\u2010Universidad de Buenos Aires Buenos Aires 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